关节炎,一种普遍的关节炎症,对有效的治疗干预措施提出了挑战,与常规治疗往往疗效有限,并伴有不良反应。近年来,人们对探索天然化合物的兴趣日益浓厚,特别是植物成分,以其抗炎和关节保护特性而闻名。这篇综述旨在阐明采用具有植物成分的纳米治疗方法来增强关节炎管理的潜力。纳米技术与植物成分的整合成为一种有前途的策略,解决传统关节炎治疗的局限性。纳米载体如脂质体和纳米颗粒为靶向药物递送提供了平台,提高植物成分的生物利用度。此外,植物成分的联合作用可用于靶向关节炎发病机理中的多种途径,包括炎症,氧化应激,和软骨退化。关键的植物成分,比如姜黄素,白藜芦醇,还有槲皮素,表现出抗炎和免疫调节特性。然而,它们的治疗潜力往往受到溶解度差等挑战的阻碍,稳定性,和生物利用度。纳米载体通过增强药代动力学和实现持续释放提供解决方案,从而提高整体疗效。这篇综述探讨了植物成分及其纳米制剂抗关节炎作用的潜在机制,包括促炎细胞因子的调节,抑制基质金属蛋白酶,和减少氧化应激。总之,植物成分与纳米技术的整合为开发靶向和有效的关节炎疗法提供了一个有希望的途径。这份全面的综述为研究人员提供了宝贵的资源,临床医生,和制药开发商寻求创新的方法来解决与关节炎管理相关的复杂挑战。
Arthritis, a prevalent inflammatory joint condition, presents challenges for effective therapeutic interventions, with conventional treatments often limited in efficacy and associated with adverse effects. Recent years have witnessed a growing interest in exploring natural compounds, particularly
phytoconstituents, renowned for their anti-inflammatory and joint-protective properties. This review aims to illuminate the potential of employing nanotherapeutic approaches with
phytoconstituents for enhanced arthritis management. The integration of nanotechnology with
phytoconstituents emerges as a promising strategy, addressing limitations in traditional arthritis treatments. Nanocarriers like liposomes and nanoparticles provide a platform for targeted drug delivery, improving the bioavailability of phytoconstituents. Furthermore, the combined effects of
phytoconstituents can be leveraged to target multiple pathways in arthritis pathogenesis, including inflammation, oxidative stress, and cartilage degradation. Key phytoconstituents, such as curcumin, resveratrol, and quercetin, exhibit anti-inflammatory and immunomodulatory properties. Nevertheless, their therapeutic potential is often impeded by challenges like poor solubility, stability, and bioavailability. Nanocarriers offer solutions by enhancing pharmacokinetics and enabling sustained release, thereby boosting overall therapeutic efficacy. The review explores the mechanisms underlying the anti-arthritic effects of phytoconstituents and their nanoformulations, including the modulation of pro-inflammatory cytokines, inhibition of matrix metalloproteinases, and reduction of oxidative stress. In summary, the integration of
phytoconstituents with nanotechnology presents a promising avenue for developing targeted and effective arthritis therapies. This comprehensive review serves as a valuable resource for researchers, clinicians, and pharmaceutical developers seeking innovative approaches to address the intricate challenges associated with arthritis management.