路易体痴呆(LBD)位于神经退行性疾病的融合,提出了一个复杂而多样的临床困境。大脑中异常蛋白质的积累,即,路易体会导致典型的神经功能紊乱,导致一系列的认知,电机,和精神症状对受影响个体的整体福祉和生活质量有重大影响。这种疾病没有明确的治疗方法;然而,已经尝试了几种非药理学和药理学方式,但疗效可疑。这项研究的目的是找出不同的介入策略在疾病中的作用。多奈哌齐,利伐斯的明,美金刚,加兰他敏是LBD的常用药物。再加上这个,左旋多巴,抗精神病药,阿莫达非尼,吡拉西坦,还使用了传统的药物,如yokukansan,当指示。谈到非药理措施,锻炼,物理治疗,多组分疗法,职业治疗,心理行为矫正,经颅刺激,和深部脑刺激已被用于可变的功效。浅谈LBD治疗的最新进展,各种疾病改善疗法,如氨溴索,奈拉马莫德,irsenontrine,尼洛替尼,博舒替尼,沃多替尼,瘦肉精,特拉唑嗪,elayta,fosgonimeton,Anle138b正在出现。然而,有药物仍处于临床试验的不同阶段,在临床实践中并不常用。随着不同的药理学和非药理学模式,我们有用于治疗LBD,所有这些都只提供症状缓解。作为一种退行性疾病,只有通过再生措施才能明确治愈这种疾病。
Lewy body dementia (LBD) is situated at the convergence of neurodegenerative disorders, posing an intricate and diverse clinical dilemma. The accumulation of abnormal protein in the brain, namely, the Lewy body causes disturbances in typical neural functioning, leading to a range of cognitive, motor, and mental symptoms that have a substantial influence on the overall well-being and quality of life of affected individuals. There is no definitive cure for the disease; however, several nonpharmacological and pharmacological modalities have been tried with questionable efficacies. The aim of this study is to figure out the role of different interventional strategies in the disease. Donepezil, rivastigmine, memantine, and galantamine were the commonly used drugs for LBD. Together with that, levodopa, antipsychotics, armodafinil, piracetam, and traditional medications like yokukansan were also used, when indicated. Talking about nonpharmacological measures, exercise, physical therapy, multicomponent therapy, occupational therapy, psychobehavioral modification, transcranial stimulation, and deep brain stimulation have been used with variable efficacies. Talking about recent advances in the treatment of LBD, various disease-modifying therapies like ambroxol, neflamapimod, irsenontrine, nilotinib, bosutinib, vodobatinib, clenbuterol, terazosin, elayta, fosgonimeton, and anle138b are emerging out. However, there drugs are still in the different phases of clinical trials and are not commonly used in clinical practice. With the different pharmacological and nonpharmacological modalities we have for treatment of LBD, all of them offer symptomatic relief only. Being a degenerative disease, definite cure of the disease can only be possible with regenerative measures.