PDF(Pubmed)
Abstract：
Parkinson\'s disease (PD) is the second most common progressive neurodegenerative disease characterized by the presence of dopaminergic neuronal loss and motor disorders. PD dementia (PDD) is a cognitive disorder that affects many PD patients. We have previously demonstrated the proinflammatory role of the glia maturation factor (GMF) in neuroinflammation and neurodegeneration in AD, PD, traumatic brain injury (TBI), and experimental autoimmune encephalomyelitis (EAE) in human brains and animal models. The purpose of this study was to investigate the expression of the GMF in the human PDD brain. We analyzed the expression pattern of the GMF protein in conjunction with amyloid plaques (APs) and neurofibrillary tangles (NFTs) in the substantia nigra (SN) and striatum of PDD brains using immunostaining. We detected a large number of GMF-positive glial fibrillary acidic protein (GFAP) reactive astrocytes, especially abundant in areas with degenerating dopaminergic neurons within the SN and striatum in PDD. Additionally, we observed excess levels of GMF in glial cells in the vicinity of APs, and NFTs in the SN and striatum of PDD and non-PDD patients. We found that the majority of GMF-positive immunoreactive glial cells were co-localized with GFAP-reactive astrocytes. Our findings suggest that the GMF may be involved in the pathogenesis of PDD.
摘要：
帕金森病（PD）是第二常见的进行性神经退行性疾病，其特征是多巴胺能神经元丢失和运动障碍。PD痴呆(PDD)是影响许多PD患者的认知障碍。我们先前已经证明了神经胶质成熟因子（GMF）在AD的神经炎症和神经变性中的促炎作用，PD,创伤性脑损伤（TBI），以及人脑和动物模型中的实验性自身免疫性脑脊髓炎（EAE）。本研究的目的是研究GMF在人类PDD脑中的表达。我们使用免疫染色分析了PDD大脑黑质（SN）和纹状体中GMF蛋白与淀粉样蛋白斑（AP）和神经原纤维缠结（NFT）的表达模式。我们检测到大量GMF阳性胶质纤维酸性蛋白（GFAP）反应性星形胶质细胞，特别是在PDD中SN和纹状体内多巴胺能神经元退化的区域。此外,我们在APs附近的神经胶质细胞中观察到过量的GMF，PDD和非PDD患者的SN和纹状体中的NFTs。我们发现大多数GMF阳性免疫反应性神经胶质细胞与GFAP反应性星形胶质细胞共定位。我们的发现表明GMF可能参与了PDD的发病机理。
