PDF(Pubmed)
Abstract：
UNASSIGNED: In patients with Parkinson\'s disease (PD), low cerebrospinal fluid (CSF) amyloid beta 1-42 (Ab42) at baseline is the most consistent CSF biomarker as a risk factor for developing dementia. Low CSF Ab42 is, however, a typical hallmark of Alzheimer\'s disease (AD). Hence, low CSF Ab42 in patients with PD may indicate presence of comorbid AD pathology and may predict a more AD-like cognitive profile when they develop dementia. Our study aimed to investigate if low CSF Ab42 at baseline is associated with a more AD-like cognitive profile in PD patients with dementia.
UNASSIGNED: In a prospectively followed-up, population-based cohort of newly diagnosed PD patients, we compared the cognitive profile of dementia in those with a low CSF Ab42 level at baseline with that of patients who had normal levels at the time when they developed dementia. Four different cognitive domain z-scores (memory, attention, executive, visuospatial) were calculated. Patients were subdivided into three tertiles or categorized dichotomously based on the baseline CSF Ab42 levels as measured by electrochemiluminescence and ELISA.
UNASSIGNED: During 10-year follow-up, 37 patients met the inclusion criteria. Memory domain composite z-scores, memory subtest z-scores, and the difference between long-delay free recall versus recognition scores were not significantly different between the groups. Composite z-scores of visuospatial functions significantly differed between the tertiles, which was not significant after Bonferroni correction. In the dichotomous group analysis, z-scores of visuospatial functions significantly differed between the two groups. The other cognitive domain z-scores were not significantly different.
UNASSIGNED: In patients with PD dementia, low CSF Ab42 level at baseline is not associated with a specific cognitive profile.
UNASSIGNED: In a prospectively followed-up, population-based cohort of newly diagnosed PD patients, we compared the cognitive profile of dementia in those with a low CSF Ab42 level at baseline with that of patients who had normal levels at the time when they developed dementia. Four different cognitive domain z-scores (memory, attention, executive, visuospatial) were calculated. Patients were subdivided into three tertiles or categorized dichotomously based on the baseline CSF Ab42 levels as measured by electrochemiluminescence and ELISA.
UNASSIGNED: During 10-year follow-up, 37 patients met the inclusion criteria. Memory domain composite z-scores, memory subtest z-scores, and the difference between long-delay free recall versus recognition scores were not significantly different between the groups. Composite z-scores of visuospatial functions significantly differed between the tertiles, which was not significant after Bonferroni correction. In the dichotomous group analysis, z-scores of visuospatial functions significantly differed between the two groups. The other cognitive domain z-scores were not significantly different.
UNASSIGNED: In patients with PD dementia, low CSF Ab42 level at baseline is not associated with a specific cognitive profile.
摘要：
■在帕金森病（PD）患者中，基线时低脑脊液(CSF)淀粉样β1-42(Ab42)是最一致的CSF生物标志物,是发生痴呆的危险因素.低脑脊液Ab42是，然而,阿尔茨海默病（AD）的典型标志。因此，PD患者的CSFAb42水平较低可能表明存在合并症AD病理,并且当他们发展为痴呆时,可能预测更多类似AD的认知特征.我们的研究旨在调查基线时CSFAb42低是否与PD痴呆患者的AD样认知特征相关。
■在前瞻性随访中，基于人群的新诊断PD患者队列，我们比较了基线时CSFAb42水平较低的患者与发展为痴呆时水平正常的患者的痴呆认知特征.四种不同的认知域z分数(记忆，注意,Executive,视觉空间)进行了计算。根据通过电化学发光和ELISA测量的基线CSFAb42水平，将患者细分为三个三分位数或二分分类。
■在10年的随访中，37例患者符合纳入标准。内存域复合z分数，记忆子测试z分数，两组之间的长时间免费回忆与识别得分之间的差异无显着差异。视觉空间功能的复合z得分在三元之间显着不同，这在Bonferroni校正后并不显著。在二分法组分析中，两组之间的视觉空间功能z得分显着不同。其他认知域z得分没有显着差异。
■在PD痴呆患者中，基线时CSFAb42水平低与特定认知特征无关.
■在前瞻性随访中，基于人群的新诊断PD患者队列，我们比较了基线时CSFAb42水平较低的患者与发展为痴呆时水平正常的患者的痴呆认知特征.四种不同的认知域z分数(记忆，注意,Executive,视觉空间)进行了计算。根据通过电化学发光和ELISA测量的基线CSFAb42水平，将患者细分为三个三分位数或二分分类。
■在10年的随访中，37例患者符合纳入标准。内存域复合z分数，记忆子测试z分数，两组之间的长时间免费回忆与识别得分之间的差异无显着差异。视觉空间功能的复合z得分在三元之间显着不同，这在Bonferroni校正后并不显著。在二分法组分析中，两组之间的视觉空间功能z得分显着不同。其他认知域z得分没有显着差异。
■在PD痴呆患者中，基线时CSFAb42水平低与特定认知特征无关.
