■腹腔镜检查在胆囊癌(GBC)分期中可能起作用,根治,和胆囊癌的缓解。然而,一些研究提倡使用腹腔镜方法,并得出结论这种方法的安全性.本研究旨在确定非转移性GBC患者开腹和腹腔镜胆囊切除术之间的安全性和可行性。
■在MEDLINE中进行了系统的数据库搜索,Embase,和谷歌学者的相关文章。因此,这些研究的清单,临床试验,截至2021年5月以英文出版,已获得,纳入14项研究,使用RevMan软件5.3(北欧Cochrane中心)进行统计分析。
■14项研究中有13项报告了5年生存率(1388例患者),并比较了腹腔镜和开放方法。研究之间没有显著的异质性(卡方,10.66;df,12;I2,0%)。开放组的总生存率显着提高(389/850vs194/538或1.45,95%CI(1.12-1.88),P值,0.005).复发率无显著差异,手术时间,失血,淋巴结产量,开放组和腹腔镜组之间的术后并发症。
■本研究表明,与腹腔镜手术相比,开腹手术的总生存率显著提高。复发率没有差异,手术时间,失血,淋巴结产量,开腹和腹腔镜胆囊切除术组的术后并发症。
UNASSIGNED: Laparoscopy in gallbladder cancer (GBC) has a possible role in staging, radical cure, and palliation in gallbladder cancer. However, a few studies have advocated the use of laparoscopic approach and concluded the safety of this approach. This present study was undertaken to determine the safety and feasibility between
open and laparoscopic cholecystectomy in patients with the non-metastatic GBC.
UNASSIGNED: A systematic database search was performed in MEDLINE, Embase, and Google Scholar for relevant articles. As a result, a list of such studies, clinical trials, published in English up to May 2021, was obtained,14 studies were included and statistical analysis was conducted using RevMan software 5.3 (The Nordic Cochrane Centre).
UNASSIGNED: The 5-year survival rate was reported in 13 out of 14 studies (1388 patients), and all compared laparoscopic and
open approach. There was no significant heterogeneity in between the studies (chi-square, 10.66; df, 12; I2, 0%). There was significant higher overall survival in
open group (389/850 vs 194/538 or 1.45, 95% CI (1.12-1.88), P value, 0.005). There was no significant difference in recurrence rate, operative time, blood loss, lymph node yield, and postoperative complication in between
open and laparoscopic groups.
UNASSIGNED: Our present study demonstrates that overall survival is significantly increased with
open approach when compared with laparoscopic approach. There is no difference in recurrence rate, operative time, blood loss, lymph node yield, and postoperative complications between the open and laparoscopic cholecystectomy groups.