Abstract：
UNASSIGNED: The indication of laparoscopic liver resection (LLR) for treating large hepatocellular carcinoma (HCC) is controversial. In this study, we compared the short-term and long-term outcomes of LLR and open liver resection (OLR) for large HCC.
UNASSIGNED: We searched eligible articles about LLR versus OLR for large HCC in PubMed, Cochrane Library, and EMBASE and performed a meta-analysis.
UNASSIGNED: Eight publications involving 1,338 patients were included. Among them, 495 underwent LLR and 843 underwent OLR. The operation time was longer in the LLR group (MD: 22.23, 95% CI: 4.14-40.33, p = 0.02). but the postoperative hospital stay time was significantly shorter (MD : -4.88, CI: -5.55 to -4.23, p < 0.00001), and the incidence of total postoperative complications and major complications were significantly fewer (OR: 0.49, 95% CI:0.37-0.66, p < 0.00001; OR: 0.54, 95% CI:0.36 - 0.82, p = 0.003, respectively). Patients in the laparoscopic group had no significant difference in intraoperative blood loss, intraoperative transfusion rate, resection margin size, R0 resection rate, three-year overall survival (OS) and three-year disease-free survival (DFS).
UNASSIGNED: LLR for large HCC is safe and feasible. This surgical strategy will not affect the long-term outcomes of patients.
UNASSIGNED: We searched eligible articles about LLR versus OLR for large HCC in PubMed, Cochrane Library, and EMBASE and performed a meta-analysis.
UNASSIGNED: Eight publications involving 1,338 patients were included. Among them, 495 underwent LLR and 843 underwent OLR. The operation time was longer in the LLR group (MD: 22.23, 95% CI: 4.14-40.33, p = 0.02). but the postoperative hospital stay time was significantly shorter (MD : -4.88, CI: -5.55 to -4.23, p < 0.00001), and the incidence of total postoperative complications and major complications were significantly fewer (OR: 0.49, 95% CI:0.37-0.66, p < 0.00001; OR: 0.54, 95% CI:0.36 - 0.82, p = 0.003, respectively). Patients in the laparoscopic group had no significant difference in intraoperative blood loss, intraoperative transfusion rate, resection margin size, R0 resection rate, three-year overall survival (OS) and three-year disease-free survival (DFS).
UNASSIGNED: LLR for large HCC is safe and feasible. This surgical strategy will not affect the long-term outcomes of patients.
摘要：
■腹腔镜肝切除术（LLR）治疗大肝细胞癌（HCC）的适应症存在争议。在这项研究中,我们比较了LLR和开放式肝切除术(OLR)治疗大型HCC的短期和长期结局.
■我们在PubMed中搜索了有关LLR与OLR的大型HCC的合格文章，科克伦图书馆,和EMBASE，并进行了荟萃分析。
■纳入了8篇出版物，涉及1,338例患者。其中,495例接受LLR，843例接受OLR。LLR组手术时间较长(MD:22.23,95%CI:4.14~40.33,p=0.02)。但术后住院时间明显缩短（MD：-4.88，CI：-5.55至-4.23，p<0.00001），术后总并发症和主要并发症的发生率明显较低(OR:0.49,95%CI:0.37-0.66,p<0.00001;OR:0.54,95%CI:0.36-0.82,p=0.003)。腹腔镜组患者术中出血量差异无统计学意义,术中输血率,切除边缘大小，R0切除率,3年总生存期（OS）和3年无病生存期（DFS）。
■大型HCC的LLR是安全可行的。这种手术策略不会影响患者的长期预后。
■我们在PubMed中搜索了有关LLR与OLR的大型HCC的合格文章，科克伦图书馆,和EMBASE，并进行了荟萃分析。
■纳入了8篇出版物，涉及1,338例患者。其中,495例接受LLR，843例接受OLR。LLR组手术时间较长(MD:22.23,95%CI:4.14~40.33,p=0.02)。但术后住院时间明显缩短（MD：-4.88，CI：-5.55至-4.23，p<0.00001），术后总并发症和主要并发症的发生率明显较低(OR:0.49,95%CI:0.37-0.66,p<0.00001;OR:0.54,95%CI:0.36-0.82,p=0.003)。腹腔镜组患者术中出血量差异无统计学意义,术中输血率,切除边缘大小，R0切除率,3年总生存期（OS）和3年无病生存期（DFS）。
■大型HCC的LLR是安全可行的。这种手术策略不会影响患者的长期预后。
