%0 Journal Article
%T A meta-analysis: laparoscopic versus open liver resection for large hepatocellular carcinoma.
%A Peng Z
%A Zhu ZR
%A He CY
%A Huang H
%J Minim Invasive Ther Allied Technol
%V 0
%N 0
%D 2024 Apr 18
%M 38634257
暂无%R 10.1080/13645706.2024.2334762
%X <B>UNASSIGNED: </B>The indication of laparoscopic liver resection (LLR) for treating large hepatocellular carcinoma (HCC) is controversial. In this study, we compared the short-term and long-term outcomes of LLR and open liver resection (OLR) for large HCC.<BR><B>UNASSIGNED: </B>We searched eligible articles about LLR versus OLR for large HCC in PubMed, Cochrane Library, and EMBASE and performed a meta-analysis.<BR><B>UNASSIGNED: </B>Eight publications involving 1,338 patients were included. Among them, 495 underwent LLR and 843 underwent OLR. The operation time was longer in the LLR group (MD: 22.23, 95% CI: 4.14-40.33, p = 0.02). but the postoperative hospital stay time was significantly shorter (MD : -4.88, CI: -5.55 to -4.23, p < 0.00001), and the incidence of total postoperative complications and major complications were significantly fewer (OR: 0.49, 95% CI:0.37-0.66, p < 0.00001; OR: 0.54, 95% CI:0.36 - 0.82, p = 0.003, respectively). Patients in the laparoscopic group had no significant difference in intraoperative blood loss, intraoperative transfusion rate, resection margin size, R0 resection rate, three-year overall survival (OS) and three-year disease-free survival (DFS).<BR><B>UNASSIGNED: </B>LLR for large HCC is safe and feasible. This surgical strategy will not affect the long-term outcomes of patients.