目的:对阻塞性睡眠呼吸暂停综合征(OSAS)与肾损伤的相关性进行Meta分析。
方法:文献检索在PubMed,数据库建立之日至2024年6月30日之间的Embase和Ovid-Medline数据库。关键词包括阻塞性睡眠呼吸暂停低通气综合征,睡眠呼吸暂停低通气综合征,肾损伤,和相关性。两名研究人员根据资格标准独立筛选标题和摘要,然后提取数据并评估质量,并使用ReviewManager5.3进行数据处理。所有分析方法均基于PRISMA。
结果:最后,纳入了8项符合纳入标准的研究,分析阻塞性睡眠呼吸暂停综合征与血清胱抑素C的关系。同质性检验显示(P<0.01,I2=98%),从荟萃分析结果来看,可以知道,OSAS患者的血清胱抑素C水平明显高于对照组(OR=1.12,95%CI0.96-1.28,P<0.01)。分析OSAS与血肌酐的关系,同质性检验显示(P<0.01,I2=96%)。从荟萃分析结果来看,可以知道阻塞性睡眠呼吸暂停综合征的血清肌酐水平明显高于对照组(OR=1.01,95%CI0.85〜1.17,P<0.01)。分析阻塞性睡眠呼吸暂停综合征与血清尿素氮的关系,同质性检验显示(P<0.01,I2=91%)。从荟萃分析结果来看,可以知道OSAS的血清尿素氮明显高于对照组(OR=1.38,95%CI01.17〜1.59,P<0.01)。
结论:已经纳入了8篇文章来确定阻塞性睡眠呼吸暂停综合征与肾损伤之间的相关性,研究发现阻塞性睡眠呼吸暂停综合征与肾损伤密切相关,两者可能是彼此的危险因素。
OBJECTIVE: To conduct a meta-analysis on the correlation between obstructive sleep apnea syndrome (OSAS) and renal injury.
METHODS: Literature search was carried out in PubMed, Embase and Ovid-Medline databases between the date of database establishment and June 30th 2024. The keywords included obstructive sleep apnea hypopnea syndrome, sleep apnea hypopnea syndrome, renal injury, and correlation. Two researchers 1st independently screened the titles and abstracts based on the eligibility criteria, then extracted the data and evaluated the quality, and used Review Manager 5.3 for data processing. All analysis methods were based on PRISMA.
RESULTS: Finally, 8 studies that matched the inclusion criteria were included, and the relationship between obstructive sleep apnea syndrome and serum cystatin C was analyzed. The homogeneity test showed (P < 0.01, I2 = 98%), and from the meta-analysis results, it could be known that the level of serum cystatin C in sufferers with OSAS was obviously greater than the control one (OR = 1.12, 95% CI 0.96-1.28, P < 0.01). The relationship between OSAS and serum creatinine was analyzed, and homogeneity test showed (P < 0.01, I2 = 96%). From the meta analysis result, it could be known that the serum creatinine level of obstructive sleep apnea syndrome was obviously greater than the control one (OR = 1.01, 95% CI 0.85 ~ 1.17, P < 0.01). The relationship between obstructive sleep apnea syndrome with serum urea nitrogen was analyzed, and homogeneity test showed (P < 0.01, I2 = 91%). From the meta-analysis results, it could be known that serum urea nitrogen of OSAS was obviously greater than the control one (OR = 1.38, 95% CI 01.17 ~ 1.59, P < 0.01).
CONCLUSIONS: Eight articles have been included to determine the correlation between obstructive sleep apnea syndrome and renal injury, and it has been found that obstructive sleep apnea syndrome is closely related to renal injury, and the two may be risk factors for each other.