Abstract：
UNASSIGNED: To reveal changes in choroidal thickness, retinal vessel density, and serum HIF-1α and TNF-α levels in obstructive sleep apnea syndrome (OSAS) and their correlation.
UNASSIGNED: This prospective case-control study included 118 patients divided into mild-to-moderate OSAS (n = 40), severe OSAS (n = 39), and a control group (n = 39). Choroidal thickness was evaluated with OCT, vessel density with OCTA, AHI index with polysomnography, and serum HIF-1α and TNF-α levels were analyzed using the enzyme-linked immunosorbent assay.
UNASSIGNED: The serum HIF-1α values of the participants in the mild-moderate OSAS and severe OSAS groups were [893.25(406.7-2068) and 1027(453-2527), respectively], and were both significantly higher than the control group [(521.5(231.6-2741))] (p < 0.001). Serum TNF-α levels did not differ significantly between the groups (p = 0.051).). Subfoveal choroidal thickness (SFCT) values of the severe OSAS groups were significantly lower than the control group (p < 0.05). The superficial and deep capillary plexus vascular density (SVD and DVD) values of the severe OSAS group were lower than the control group (p < 0.05). Serum HIF-1α and TNF-α levels of all participants were negatively correlated with both their SVD values (p < 0.05, r: -0.220 and p < 0.05, r: -0.252, respectively) and their DVD values (p < 0.001, r: -0.324 and p = 0.001, r: -0.299, respectively).
UNASSIGNED: Increased serum levels of inflammatory mediators (HIF-1α ve TNF-α) in OSAS cause a decrease in SFCT, SVD, and DVD, which is an indication of systemic vascular damage. Further research on developing treatment strategies to modulate TNF-α ve HIF-1α may help recede vascular morbidity in OSAS patients.
UNASSIGNED: This prospective case-control study included 118 patients divided into mild-to-moderate OSAS (n = 40), severe OSAS (n = 39), and a control group (n = 39). Choroidal thickness was evaluated with OCT, vessel density with OCTA, AHI index with polysomnography, and serum HIF-1α and TNF-α levels were analyzed using the enzyme-linked immunosorbent assay.
UNASSIGNED: The serum HIF-1α values of the participants in the mild-moderate OSAS and severe OSAS groups were [893.25(406.7-2068) and 1027(453-2527), respectively], and were both significantly higher than the control group [(521.5(231.6-2741))] (p < 0.001). Serum TNF-α levels did not differ significantly between the groups (p = 0.051).). Subfoveal choroidal thickness (SFCT) values of the severe OSAS groups were significantly lower than the control group (p < 0.05). The superficial and deep capillary plexus vascular density (SVD and DVD) values of the severe OSAS group were lower than the control group (p < 0.05). Serum HIF-1α and TNF-α levels of all participants were negatively correlated with both their SVD values (p < 0.05, r: -0.220 and p < 0.05, r: -0.252, respectively) and their DVD values (p < 0.001, r: -0.324 and p = 0.001, r: -0.299, respectively).
UNASSIGNED: Increased serum levels of inflammatory mediators (HIF-1α ve TNF-α) in OSAS cause a decrease in SFCT, SVD, and DVD, which is an indication of systemic vascular damage. Further research on developing treatment strategies to modulate TNF-α ve HIF-1α may help recede vascular morbidity in OSAS patients.
摘要：
■为了揭示脉络膜厚度的变化，视网膜血管密度,阻塞性睡眠呼吸暂停综合征(OSAS)患者血清HIF-1α和TNF-α水平及其相关性。
■这项前瞻性病例对照研究包括118名患者，分为轻度至中度OSAS（n=40），严重OSAS（n=39），和对照组(n=39)。用OCT评估脉络膜厚度，OCTA的血管密度，多导睡眠图AHI指数，采用酶联免疫吸附试验分析血清HIF-1α和TNF-α水平。
■轻度-中度OSAS和重度OSAS组参与者的血清HIF-1α值分别为[893.25（406.7-2068）和1027（453-2527），分别]，并且均显着高于对照组[（521.5（231.6-2741））]（p<0.001）。两组之间的血清TNF-α水平没有显着差异（p=0.051）。).重度OSAS组的中心凹下脉络膜厚度(SFCT)值明显低于对照组(p<0.05)。重度OSAS组浅层和深层毛细血管丛血管密度(SVD和DVD)值均低于对照组(p<0.05)。所有参与者的血清HIF-1α和TNF-α水平与他们的SVD值(分别为p<0.05,r:-0.220和p<0.05,r:-0.252)和他们的DVD值(分别为p<0.001,r:-0.324和p=0.001,r:-0.299)均呈负相关。
■OSAS患者血清炎症介质（HIF-1αveTNF-α）水平升高导致SFCT降低，SVD,DVD,这是全身血管损伤的迹象.关于开发治疗策略以调节TNF-αveHIF-1α的进一步研究可能有助于降低OSAS患者的血管发病率。
■这项前瞻性病例对照研究包括118名患者，分为轻度至中度OSAS（n=40），严重OSAS（n=39），和对照组(n=39)。用OCT评估脉络膜厚度，OCTA的血管密度，多导睡眠图AHI指数，采用酶联免疫吸附试验分析血清HIF-1α和TNF-α水平。
■轻度-中度OSAS和重度OSAS组参与者的血清HIF-1α值分别为[893.25（406.7-2068）和1027（453-2527），分别]，并且均显着高于对照组[（521.5（231.6-2741））]（p<0.001）。两组之间的血清TNF-α水平没有显着差异（p=0.051）。).重度OSAS组的中心凹下脉络膜厚度(SFCT)值明显低于对照组(p<0.05)。重度OSAS组浅层和深层毛细血管丛血管密度(SVD和DVD)值均低于对照组(p<0.05)。所有参与者的血清HIF-1α和TNF-α水平与他们的SVD值(分别为p<0.05,r:-0.220和p<0.05,r:-0.252)和他们的DVD值(分别为p<0.001,r:-0.324和p=0.001,r:-0.299)均呈负相关。
■OSAS患者血清炎症介质（HIF-1αveTNF-α）水平升高导致SFCT降低，SVD,DVD,这是全身血管损伤的迹象.关于开发治疗策略以调节TNF-αveHIF-1α的进一步研究可能有助于降低OSAS患者的血管发病率。
