四重异常高磷酸化tau,β-淀粉样蛋白,α-突触核蛋白和TDP-43神经病理学和金属固体纳米颗粒(NPs)记录在暴露于墨西哥城(MMC)污染的儿童和年轻人的大脑中。我们研究了到达去甲肾上腺素能和多巴胺能核以及小脑的环境NPs及其相关的超微结构改变。这里,我们确定蓝斑(LC)中的NP,通过透射电子显微镜(TEM)和能量色散X射线光谱法(EDX)对179位MMC居民的197个样品进行了黑质(SN)和小脑,年龄为25.9±9.2岁,年龄为63±14.5岁的7名老年人。Fe,Ti,Hg,W,在SN中鉴定出Al和Zn球形和针状NP,LC和小脑神经和血管线粒体,内质网,高尔基,神经黑色素,异染色质和核孔复合物(NPCs)以及早期和进行性神经血管损伤和小脑内皮红细胞吞噬作用。引人注目的是,FeNPs4±1nm和HgNPs8±2nm主要见于LC和SN。纳米颗粒可以作为错误折叠蛋白质的共同点,并且可以在改变和阻碍NPC中发挥作用。NP/一氧化碳相关性可能有助于评估都市人早期神经变性的风险。生命早期的NP暴露对大脑造成致命神经系统结局的高风险。NP排放源应该被清楚地认识到,受管制,并受到监控;子孙后代处于危险之中。
Quadruple aberrant hyperphosphorylated tau, beta-amyloid, α-synuclein and TDP-43 neuropathology and metal solid nanoparticles (NPs) are documented in the brains of children and young adults exposed to Metropolitan Mexico City (MMC) pollution. We investigated environmental NPs reaching noradrenergic and dopaminergic nuclei and the cerebellum and their associated ultrastructural alterations. Here, we identify NPs in the locus coeruleus (LC), substantia nigrae (SN) and cerebellum by transmission electron microscopy (TEM) and energy-dispersive X-ray spectrometry (EDX) in 197 samples from 179 MMC residents, aged 25.9 ± 9.2 years and seven older adults aged 63 ± 14.5 years. Fe, Ti, Hg, W, Al and Zn spherical and acicular NPs were identified in the SN, LC and cerebellar neural and vascular mitochondria, endoplasmic reticulum, Golgi, neuromelanin, heterochromatin and nuclear pore complexes (NPCs) along with early and progressive neurovascular damage and cerebellar endothelial erythrophagocytosis. Strikingly, FeNPs 4 ± 1 nm and Hg NPs 8 ± 2 nm were seen predominantly in the LC and SN. Nanoparticles could serve as a common denominator for misfolded proteins and could play a role in altering and obstructing NPCs. The NPs/carbon monoxide correlation is potentially useful for evaluating early neurodegeneration risk in urbanites. Early life NP exposures pose high risk to brains for development of lethal neurologic outcomes. NP emissions sources ought to be clearly recognized, regulated, and monitored; future generations are at stake.