Abstract：
The nuclear pore complexes are essential for cellular and molecular processes such as trafficking between the cytoplasm and the nucleus, chromatin, transcriptional outputs, and DNA damage repair. Nucleoporins, components of nuclear pore complexes, have been linked to cancer through nucleo-cytoplasmic cargo trafficking, cell division, signalling pathways, chromatin-related processes, and protein stability and degradation. This study aims to understand how nucleoporins specifically contribute to cancer proliferation and progression across various cancer types. Accordingly, angles such as nuclear trafficking, fusion proteins, tumour suppressors, signalling pathways, tumour microenvironment, nucleosomes, and chromatin processes were found to bridge the function of nucleoporins and cancer progression, and the underlying mechanisms have been analysed in this study. A deep understanding of the function of nucleoporins in cancer progression will pave the way for the effective targeting of these molecules for therapeutic gain. Improved treatment responses can enhance the quality of life of cancer patients.
摘要：
核孔复合物对于细胞和分子过程是必不可少的，例如细胞质和细胞核之间的运输，染色质,转录输出，和DNA损伤修复。核孔蛋白,核孔复合物的成分，通过核质-细胞质货物贩运与癌症有关，细胞分裂,信号通路，染色质相关过程，和蛋白质的稳定性和降解。这项研究旨在了解核孔蛋白如何特别促进各种癌症类型的癌症增殖和进展。因此，比如核贩运，融合蛋白,肿瘤抑制剂，信号通路，肿瘤微环境，核小体,染色质过程被发现桥接核孔蛋白的功能和癌症进展，并在这项研究中分析了潜在的机制。深入了解核孔蛋白在癌症进展中的功能将为有效靶向这些分子以获得治疗效果铺平道路。改善的治疗反应可以提高癌症患者的生活质量。
