暂无摘要。

OBJECTIVE: After 9/11, multiple government agencies instituted programs aimed at developing medical radiation countermeasures (MRCs) for two syndromes lethal within weeks of a limited nuclear attack; the hematopoietic-acute radiation syndrome (H-ARS) and the higher-dose gastrointestinal-acute radiation syndrome (GI-ARS). While re-purposing drugs that enhance marrow repopulation treats H-ARS, no mitigator protects GI tract.
METHODS: We recently reported anti-ceramide 6B5 single-chain variable fragment (scFv) pre-treatment abrogates ongoing small intestinal endothelial apoptosis to rescue Lgr5+ stem cells, preventing GI-ARS lethality in C57B/L6J mice. Here, with US Department of Defense support, we provide evidence that humanized anti-ceramide scFv (CX-01) is a promising prophylactic MRC for first responders, who risk exposure upon entering a radiation-contaminated site.
RESULTS: CX-01, when delivered up to 90 min before irradiation, is highly-effective in preventing small intestinal endothelial apoptosis in mice and lethality in both sexes. Unexpectedly, females require an ~2-fold higher CX-01 dose than males for full protection. CX-01 is effective subcutaneously and intramuscularly, a property critical for battlefield use. Increasing the maximally-effective dose 5-fold does not extend duration of bioeffectiveness.
CONCLUSIONS: While CX-01 prevents GI-ARS lethality, structural modification to extend half-life may be necessary to optimize first responder prophylaxis.

Three nuclear weapons tests were conducted in the 1950s at the Montebello Islands, Western Australia. The detonations were of different yields and configurations (two tower tests, one ship test), and led to substantial radionuclide contamination within the surrounding terrestrial and marine ecosystems. The region possesses great ecological and recreational significance, particularly within the marine environment. However, studies conducted so far have largely neglected the marine ecosystem which makes up the majority of the Montebello Island Marine Park and in which most test fallout would have deposited. Here we investigated the distribution of the transuranic radionuclides 238Pu, 239,240Pu and 241Am in marine sediment from the Montebello Islands. Marine sediment samples near Operation Mosaic G2 and Operation Hurricane were collected and analysed by gamma and alpha spectrometry. Activity concentrations of 239,240Pu across both series ranged from 45 to 2900 Bq kg-1, while 241Am levels ranged from 2.8 to 70 Bq kg-1. Higher activity concentrations were observed in sediment near the land-based, higher yield Mosaic G2 test, compared with the ship-based, lower yield Hurricane test. Sediment samples located closer to the detonation site were also observed to have higher activity concentrations. Radioactive particles of 0.94 mm and 1.5 mm in diameter were identified by analysis of size-fractioned sediment via investigation of 152Eu levels, photostimulated autoradiography and point gamma spectroscopy. Particles were confirmed to have transuranic radionuclide interiors, with surface coatings which were dominated by vitrified CaCO3. Their long-term resistance to weathering and subsequent persistence in the marine environment can therefore be attributed to their coated structural form. Our study confirms the persistence of transuranic radionuclides in Montebello Island marine sediment and highlights the need for additional studies to improve our understanding of the nuclear legacy in this region.

The population in the areas neighboring the Semipalatinsk Nuclear Test Site (SNTS) in the eastern region of Kazakhstan faces increased cardiovascular disease (CVD) risk. Previous research has not explored gene polymorphisms related to CVD in this population. Therefore, the present study examines the prevalence of six CVD-associated genotypes in three generations exposed to SNTS radiation. The genotyping of ApoE Leu28 → Pro, AGT Met174 → Thr, AGT Met235 → Thr, eNOS T786 → C, PON1 Gln192 → Arg, and EDN 1 Lys198 → Asn was performed using real-time polymerase chain reaction. The present study encompassed a cohort of 218 participants with a familial history of arterial hypertension and/or carotid artery disease spanning at least three generations. The analysis unveiled significant disparities in the prevalence of ApoE Leu28 → Pro, eNOS T786 → C, and PON1 Gln192 → Arg genotypes across different generations. Furthermore, a substantial variation in the distribution of the eNOS T786 → C genotype was observed between individuals of Kazakh and Russian ethnicities. Nevertheless, no significant discrepancies were detected in the frequencies of the investigated genotypes between genders. Further research in this area is warranted to enhance the understanding of the genetic factors contributing to CVD in the population exposed to radiation from the SNTS. Specifically, future studies should broaden the scope of genetic polymorphisms investigated and include representatives of healthy individuals who have not been exposed to radiation as controls.

UNASSIGNED: The purpose of this paper is to present a practical method for quick determination of potential radiological doses and contaminations by fallout from nuclear detonations, or other releases, that includes the contributions from all nuclides. We precalculate individual (total) activities of all radionuclides from any initial cocktail and all their ingrowing progeny at a set of pinpoints in time with a logarithmic time-spacing. This is combined with the set of dose conversion factors (DCC) for any exposure pathway to obtain a time-dependent cocktail for the whole release as if it is one substance. An atmospheric dispersion model then provides the thinning coefficient of the released material to give local concentrations and dose rates. Progeny ingrowth is illustrated for pure 238 U and for a nuclear reactor that has been shut down. Efficient dose assessment is demonstrated for fallout from nuclear detonations and compared with the traditional approach of preselecting nuclides for specific endpoints and periods-of-interest. The compound cocktail DCC reduces the assessment of contaminations and potential dose-effects from fallout after a nuclear detonation to (the atmospheric dispersion of) only one tracer substance, representing any cocktail of nuclides and their progeny. This removes the need to follow all separate nuclides or an endpoint-specific preselection of \"most important nuclides.\" As the cocktail DCCs can be precalculated and the atmospheric dispersion of only one tracer substance has to be modelled, our method is fast. The model for calculating cocktail DCCs is freely available, easily coupled to any regular atmospheric dispersion model, and therefore ready for operational use by others.

Potassium iodide has demonstrated several therapeutic applications over time, being the choice for shielding the thyroid during radiation emergencies involving radioiodine release. Amidst the ongoing military conflict between Ukraine and Russia and the growing concern regarding the potential deployment of nuclear weapons, there has been a surge in the demand for potassium iodide across Europe. This work aimed to comprehensively review the current knowledge regarding the pharmacology, physiology, adverse effects, the protective role in reducing the risk of thyroid cancer and recommendations for potassium iodide use during radiation emergencies. Evidence on adverse effects is scarce, as potassium iodide is generally well-tolerated. Guidelines for thyroid blocking with potassium iodide during radiation emergencies suggest that, among populations vulnerable to radioiodine exposure, the benefits of potassium iodide outweigh the risks of adverse effects. Controversial topics surrounding the utilization of potassium iodide in radiation emergencies include the prophylaxis in iodine-deficient regions and following the detonation of dirty bombs, whether granule formulations versus tablets should be used and mental health concerns. Although the rise in demand seems to be a justified security measure, it is essential to recognize that potassium iodide protects the thyroid from radioiodine and does not impact the body\'s absorption of other radioactive materials or defend against external radiation exposure.

Vegetation and soils are taking up approximately 30% of anthropogenic carbon dioxide emissions because of small imbalances in large gross carbon exchanges from productivity and turnover that are poorly constrained. We combined a new budget of radiocarbon produced by nuclear bomb testing in the 1960s with model simulations to evaluate carbon cycling in terrestrial vegetation. We found that most state-of-the-art vegetation models used in the Coupled Model Intercomparison Project underestimated the radiocarbon accumulation in vegetation biomass. Our findings, combined with constraints on vegetation carbon stocks and productivity trends, imply that net primary productivity is likely at least 80 petagrams of carbon per year presently, compared with the 43 to 76 petagrams per year predicted by current models. Storage of anthropogenic carbon in terrestrial vegetation is likely more short-lived and vulnerable than previously predicted.

Christopher Nolan\'s Oppenheimer is in awe of physics and the power it can bestow. Its central character is both mythic and human, and the film critiques and constructs the mythology surrounding him. The film presents science and technology as the individualized work of masculine genius, though it is ultimately more interested in nuclear weapons as political objects than as technological ones. Its nuclear imaginaries contain personal anxieties and stunning spectacle but also forget the nuclear uncanny and the human scale of nuclear weapons.

In the post-Hiroshima era, atomic cities-designed to survive a nuclear attack-remain in the science fiction realm. Yet Hungarian émigré Paul Laszlo, a successful architect in Southern California suburbia, had a utopian vision for a futuristic, paradoxically luxurious atomic city he called \"Atomville,\" never built but nonetheless seriously proposed. Laszlo was one of the very few architects known to venture into atomic survival on this scale. This article focuses on why the architectural profession for the most part ignored the issues raised by the atomic bomb, and on Laszlo\'s role as an outlier. It also deals with the genesis of Atomville and its place among the many unrealized ideas put forward in the 1940s and 1950s for urban survival, including underground buildings, urban dispersal, linear cities, and cluster cities.

This article considers the Soviet Union\'s successful efforts to employ more women specialists in nuclear science and technology, from the Bolshevik revolution in 1917 and the Soviet atomic bomb project to the Cold War and the present. Despite their contributions to building a Cold War military machine, women rarely reached the pinnacle of the scientific enterprise due to persistent views about their lesser capabilities as specialists. After the collapse of the Soviet Union, in a vastly changed social, political, and cultural climate, the claimed socialist equality of women gave way to more traditional views of their status in Russian society. For the nuclear enterprise, this change emerged in activities that had disappeared under communism such as the annual \"Miss Atom\" beauty pageant, a striking departure from Soviet attempts to involve women equally in science and technology.