■天然药物在动脉粥样硬化(AS)治疗领域具有重要的研究和应用价值。这项研究是为了调查天然药物成分的影响,三七皂苷R1对动脉粥样硬化(AS)的发生发展及潜在机制的影响。
■用三七皂苷R1治疗高脂饮食和维生素D3诱导的AS大鼠6周。通过检测腹主动脉的病理变化来评估NR1对AS大鼠的改善作用。血清生化指标和腹主动脉蛋白表达,以及通过分析肠道微生物群。
■NR1组显示斑块病理明显减少。三七皂苷R1能显著改善血脂,包括TG,TC,LDL,ox-LDL,和HDL。同时,IL-6,IL-33,TNF-α,三七皂苷R1降低炎症因子和IL-1β水平。三七皂苷R1可抑制VCAM-1和ICAM-1的分泌,并提高血浆NO和eNOS的水平。此外,三七皂苷R1抑制NLRP3/裂解的Caspase-1/IL-1β炎症通路,降低JNK2/P38MAPK/VEGF内皮损伤通路的表达。粪便分析显示,三七皂苷R1通过减少病原菌(如厚壁菌和变形杆菌)的数量和增加益生菌(如拟杆菌)的数量来重塑AS大鼠的肠道菌群。
■三七皂苷R1,由于其独特的抗炎特性,可能潜在地阻止动脉粥样硬化的进展。这种机制有助于保护血管内皮免受损伤,在调节肠道微生物群失衡的同时,从而保持身体的整体健康。
UNASSIGNED: Natural medicines possess significant research and application value in the field of atherosclerosis (AS) treatment. The study was performed to investigate the impacts of a natural drug component, notoginsenoside R1, on the development of atherosclerosis (AS) and the potential mechanisms.
UNASSIGNED: Rats induced with AS by a high-fat-diet and vitamin D3 were treated with notoginsenoside R1 for six weeks. The ameliorative effect of NR1 on AS rats was assessed by detecting pathological changes in the abdominal aorta, biochemical indices in serum and protein expression in the abdominal aorta, as well as by analysing the gut microbiota.
UNASSIGNED: The NR1 group exhibited a noticeable reduction in plaque pathology. Notoginsenoside R1 can significantly improve serum lipid profiles, encompassing TG, TC, LDL, ox-LDL, and HDL. Simultaneously, IL-6, IL-33, TNF-α, and IL-1β levels are decreased by notoginsenoside R1 in lowering inflammatory elements. Notoginsenoside R1 can suppress the secretion of VCAM-1 and ICAM-1, as well as enhance the levels of plasma NO and eNOS. Furthermore, notoginsenoside R1 inhibits the NLRP3/Cleaved Caspase-1/IL-1β inflammatory pathway and reduces the expression of the JNK2/P38 MAPK/VEGF endothelial damage pathway. Fecal analysis showed that notoginsenoside R1 remodeled the gut microbiota of AS rats by decreasing the count of pathogenic bacteria (such as Firmicutes and Proteobacteria) and increasing the quantity of probiotic bacteria (such as Bacteroidetes).
UNASSIGNED: Notoginsenoside R1, due to its unique anti-inflammatory properties, may potentially prevent the progression of atherosclerosis. This mechanism helps protect the vascular endothelium from damage, while also regulating the imbalance of intestinal microbiota, thereby maintaining the overall health of the body.