背景虽然西班牙裔白人女性(HW)的乳腺癌(BC)发病率低于非西班牙裔白人女性(NHW),良性乳腺疾病(BBD)后HW女性的BC风险尚不清楚。方法我们使用基于人群的良性乳腺活检(1996-2007)比较了新墨西哥州HW和NHW女性的BBD特征和随后的BC风险。BBD被归类为非增殖性疾病(NPD),无异型增生性疾病(PDWA),或不典型增生(AH)。通过比较BBD与非BBD中BC事件的数量,使用累积发生率和相对风险(RR)将BC风险评估为绝对风险(AR)。结果本研究包括3,684名HW和6,587名患有BBD的NHW女性。HW女性的NPD比例相似(58.6%对54.3%),PDWA(21.4%对23.5%),和AH(3.6%vs.3.3%)为NHW。所有BBD女性的BC风险高于基于人群的预期率(RR=1.87),HW和NHW亚组的BC风险相似(RR=1.99vs.1.84)。不出所料,BC风险随着BBD严重程度的增加而增加,两者总体[RR=1.81(NPD),1.85(PDWA)和3.10(AH)]以及HW和NHW亚组。5年时BC的调整AR也随着BBD的严重程度而增加(HW与NHW;NPD:1.4vs.2.1%;PDWA:1.5vs.2.7%;AH:6vs.4.8%)。结论我们在HW和NHW中发现了相似的BCRR和AR。风险咨询应确保HW女性接受类似绝对风险所保证的乳腺癌临床管理。影响目前基于人群的研究为患有BBD的HW女性预防BC的临床管理提供了证据。
UNASSIGNED: Although Hispanic White (HW) females have a lower incidence of breast cancer than non-Hispanic White (NHW) females, breast cancer risk is unclear for HW females after benign breast disease (BBD).
UNASSIGNED: We compared BBD characteristics and subsequent breast cancer risk among HW and NHW females in New Mexico using a population-based collection of benign breast biopsies (1996-2007). BBD was categorized as nonproliferative disease (NPD), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH). Breast cancer risk was assessed as absolute risk (AR) using cumulative incidence and RR by comparing the number of breast cancer events in BBDs to non-BBD.
UNASSIGNED: This study included 3,684 HW and 6,587 NHW females with BBD. HW females had similar proportions of NPD (58.6% vs. 54.3%), PDWA (21.4% vs. 23.5%), and AH (3.6% vs. 3.3%) as NHW females. Breast cancer risk among all females with BBD was higher than population-based expected rates (RR, 1.87) and was similar for HW and NHW subgroups (RR = 1.99 vs. 1.84). As expected, breast cancer risk increased with increasing BBD severity, both overall [RR, 1.81 (NPD), 1.85 (PDWA), and 3.10 (AH)] and in the HW and NHW subgroups. Adjusted AR of breast cancer at 5 years also increased with the severity of BBD (HW vs. NHW; NPD: 1.4% vs. 2.1%; PDWA: 1.5% vs. 2.7%; AH: 6% vs. 4.8%).
UNASSIGNED: We found similar breast cancer RRs and ARs in HW and NHW. Risk counseling should ensure that HW females receive breast cancer clinical management warranted by their similar absolute risks.
UNASSIGNED: The present population-based provides evidence for the clinical management of HW females with BBD for the prevention of breast cancer.