S100B是S100家族的成员\“E\”螺旋环-\“F\”螺旋结构(EF)手钙结合蛋白,在多种胶质细胞中表达,选定的神经元,和各种外周细胞,发挥不同的作用。特别是,这篇综述汇编了人类发育过程中特定区域不同脑细胞中S100B的检测描述,老鼠,和老鼠。然后,它总结了S100B在差异化方面的行动,增长,以及人类和啮齿动物的神经胶质细胞和神经元细胞的成熟。特别强调S100B对星形胶质细胞分化和成熟的调控,少突胶质细胞(OL),以及在胚胎发生过程中刺激5-羟色胺能和小脑神经元的树突发育。我们还总结了与形态学改变(受损的神经突生长,神经元迁移,在神经发育和功能紊乱(体重增加速率较慢,受损的空间学习)随着暴露于压力的不同条件和刺激引起的S100B表达的变化,乙醇,可卡因和先天性疾病,如唐氏综合症。一起来看,这些证据强调了S100B在星形胶质细胞中的表达和早期作用的影响,OL,大脑发育过程中的神经元,这反映在分化的变化中,增长,和这些细胞的成熟。这允许将S100B作用的时空全景整合到发育中的大脑中的神经胶质细胞和神经元细胞中。
The S100B is a member of the S100 family of \"E\" helix-loop- \"F\" helix structure (EF) hand calcium-binding proteins expressed in diverse glial, selected neuronal, and various peripheral cells, exerting differential effects. In particular, this review compiles descriptions of the detection of S100B in different brain cells localized in specific regions during the development of humans, mice, and rats. Then, it summarizes S100B\'s actions on the differentiation, growth, and maturation of glial and neuronal cells in humans and rodents. Particular emphasis is placed on S100B regulation of the differentiation and maturation of astrocytes, oligodendrocytes (OL), and the stimulation of dendritic development in serotoninergic and cerebellar neurons during embryogenesis. We also summarized reports that associate morphological alterations (impaired neurite outgrowth, neuronal migration, altered radial glial cell morphology) of specific neural cell groups during neurodevelopment and functional disturbances (slower rate of weight gain, impaired spatial learning) with changes in the expression of S100B caused by different conditions and stimuli as exposure to stress, ethanol, cocaine and congenital conditions such as Down\'s Syndrome. Taken together, this evidence highlights the impact of the expression and early actions of S100B in astrocytes, OL, and neurons during brain development, which is reflected in the alterations in differentiation, growth, and maturation of these cells. This allows the integration of a spatiotemporal panorama of S100B actions in glial and neuronal cells in the developing brain.