Near Drowning

近溺水
  • DOI:
    文章类型: Journal Article
    背景:急性肺损伤或急性呼吸窘迫综合征(ARDS)是非致命性溺水最常见的并发症之一。尽管呼吸学会指南认可全身性皮质类固醇在ARDS中的作用,非致命性溺水所致ARDS患者全身使用皮质类固醇的证据有限.
    方法:在Pubmed,OVID,和EuropePMC,使用纳入和排除标准评估临床问题。对选定的研究进行了严格评估,并对结果进行了总结。
    结果:共选择并评估了六项回顾性研究,所有研究均显示有效性差,偏倚风险高.在六项研究中,只有4人告知我们类固醇给药对结局的影响.在两项研究中,与皮质类固醇相关的死亡率似乎更高.相反,一项研究发现,皮质类固醇组无死亡率,但对照组死亡率为100%.在另一项研究中,类固醇治疗似乎不影响住院时间或机械通气率.
    结论:非致命性溺水的皮质类固醇给药及其对临床结局的影响仍然模棱两可。皮质类固醇的常规给药是不需要的,应该在个案的基础上进行。
    BACKGROUND: Acute lung injury or acute respiratory distress syndrome (ARDS) is one of the most common complications of non-fatal drowning. Although respiratory societies\' guidelines endorse the role of systemic corticosteroids in ARDS, the evidence for systemic corticosteroid use in ARDS due to non-fatal drowning is limited.
    METHODS: A search was conducted on Pubmed, OVID, and EuropePMC, assessing the clinical question using inclusion and exclusion criteria. The selected studies were critically appraised, and the results were summarized.
    RESULTS: A total of six retrospective studies were selected and assessed, all studies showed poor validity and a high risk of bias. Out of six studies, only four informed us of steroid administration\'s effect on outcomes. In two studies, mortality associated with corticosteroid administration seemed to be higher. On the contrary, one study found no mortality in the corticosteroid group, but 100% mortality was observed in the control group. In another study, steroid therapy seemed to not affect hospital length of stay or mechanical ventilation rates.
    CONCLUSIONS: Corticosteroid administration for non-fatal drowning and its impact on clinical outcomes remains equivocal. Routine administration of corticosteroids is not indicated and should be done on a case-by-case basis.
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  • 文章类型: Journal Article
    溺水在全球范围内造成相当大的发病率和死亡率,据估计,90%的溺水是可以预防的。溺水被定义为“由于浸入/浸入液体中而导致呼吸损害的过程。急诊服务提供者应专注于气道管理和快速输送氧气,以中断溺水过程并改善患者预后。症状轻微或没有症状的患者不需要任何特定的诊断检查,除了体检和出院前4至6小时的观察。症状较严重的患者可能会出现罗音和泡沫分泌物,应使用高浓度氧气和气道正压通气进行管理。
    Drowning is responsible for considerable morbidity and mortality worldwide, and it is estimated that 90% of drownings are preventable. Drowning is defined as \"the process of experiencing respiratory impairment from submersion/immersion in liquid.\" Emergency providers should focus on airway management and rapid delivery of oxygen to interrupt the drowning process and improve patient outcomes. Patients with minimal or no symptoms do not require any specific diagnostic workup, aside from physical examination and 4 to 6 hours of observation prior to discharge. Patients with more severe symptoms may present with rales and foamy secretions, and should be managed with high-concentration oxygen and positive airway pressure.
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  • 文章类型: Review
    背景:Scedosporiumapiospermum(S.apiospermum)是一种罕见的真菌病原体,可引起播散性感染。它很少影响有免疫能力的个体,并且预后不良。
    方法:一名37岁女性肺部多发病变,大脑,和眼睛,在一场车祸中险些溺水后不久。主要症状是胸闷,四肢无力,头痛,左眼视力差.通过颅内脓肿引流液的宏基因组下一代测序(mNGS)证实了枯草菌感染,尽管最初考虑颅内转移。伏立康唑全身治疗后,她的症状明显改善;然而,由于延误诊断,她的左眼失去了视力。
    结论:虽然吸精菌感染很少见,即使在有免疫能力的患者中也应考虑。及时的诊断和治疗至关重要。伏立康唑可能是一种有效的治疗选择。
    BACKGROUND: Scedosporium apiospermum (S. apiospermum) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has a poor prognosis.
    METHODS: A 37-year-old woman presented with multiple lesions in the lungs, brain, and eyes, shortly after near drowning in a car accident. The primary symptoms were chest tightness, limb weakness, headache, and poor vision in the left eye. S. apiospermum infection was confirmed by metagenomic next-generation sequencing (mNGS) of intracranial abscess drainage fluid, although intracranial metastases were initially considered. After systemic treatment with voriconazole, her symptoms improved significantly; however, she lost vision in her left eye due to delayed diagnosis.
    CONCLUSIONS: While S. apiospermum infection is rare, it should be considered even in immunocompetent patients. Prompt diagnosis and treatment are essential. Voriconazole may be an effective treatment option.
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  • 文章类型: Review
    Scedosporiumapiospermum物种复合体是广泛分布的真菌,可以在各种污染环境中发现,包括土壤,污水,和腐烂的植被。那些具有强烈入侵潜力的机会病原体通常会影响免疫抑制人群。在有免疫能力的个体中报道了很少的丝孢子虫病病例,可能会被误诊,导致高死亡率。这里,我们报道了一例涉及肺部的全身感染的免疫功能正常的病例,大脑和脊柱,由S.apiospermum物种复合体(S.apiospermum和S.boydii)。该患者是一名老年男性,在接近溺水后持续发烧和系统感染。在他参观的两家三级医院,明确的诊断是极其困难的。入院后,他被误诊为结核感染,在通过宏基因组下一代测序诊断出夏枯草物种复杂感染之前。伏立康唑治疗后症状缓解。在目前的情况下,报道了与其病程相关的详细信息,并发表了有关Scedosporiumspp的研究。感染也进行了审查,更好地了解本病,减少误诊率。
    Scedosporium apiospermum species complex are widely distributed fungi that can be found in a variety of polluted environments, including soil, sewage, and decaying vegetation. Those opportunistic pathogens with strong potential of invasion commonly affect immunosuppressed populations However, few cases of scedosporiosis are reported in immunocompetent individuals, who might be misdiagnosed, leading to a high mortality rate. Here, we reported an immunocompetent case of systemtic infection involved in lung, brain and spine, caused by S. apiospermum species complex (S. apiospermum and S. boydii). The patient was an elderly male with persistent fever and systemtic infection after near-drowning. In the two tertiary hospitals he visited, definite diagnosis was extremely difficult. After being admitted to our hospital, he was misdiagnosed as tuberculosis infection, before diagnosis of S. apiospermum species complex infection by the metagenomic next-generation sequencing. His symptoms were alleviated after voriconazole treatment. In the present case, the details associated with its course were reported and published studies on Scedosporium spp. infection were also reviewed, for a better understanding of this disease and reducing the misdiagnosis rate.
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  • 文章类型: Case Reports
    溺水是全世界儿童发病和死亡的常见原因。缺氧,体温过低,代谢性酸中毒是这种发病率的主要原因。溺水可能导致多器官损伤,尤其是心脏损伤,在发生严重低温和低氧血症的情况下。我们报告了一个4岁女孩因溺水而被我们医院急诊科收治的病例。她的肌钙蛋白I浓度升高,ST段抬高并伴有T波倒置。然而,心血管计算机断层扫描显示冠状动脉无明显异常.我们建议这种情况下的心脏损伤是由冠状动脉痉挛引起的。据我们所知,这是学龄前儿童溺水后心脏损害并伴有心电图改变的首例病例。
    Drowning is a common cause of childhood morbidity and mortality worldwide. Anoxia, hypothermia, and metabolic acidosis are mainly responsible for this morbidity. Drowning may lead to multiple organ damage, especially cardiac damage, in cases in which severe hypothermia and hypoxemia occur. We report a case of a 4-year-old girl who was admitted to our hospital\'s Emergency Department because of drowning. She had elevated troponin I concentrations and ST-segment elevation with T wave inversion. However, cardiovascular computed tomography showed no obvious abnormalities in the coronary arteries. We suggest that cardiac damage in this situation is caused by coronary artery spasms. To the best of our knowledge, this is the first case of cardiac damage with electrocardiographic changes after drowning in a preschool child.
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  • 文章类型: Systematic Review
    Scedosporium/Lomentospora物种以腐生霉菌的形式存在,可能导致经历过溺水事件的患者严重感染。Scedosporium物种分布在世界不同地区,而Lomentosporaprolificans的地理分布相当有限。我们的目的是系统地回顾接近溺水后的scedosporiosis病例,他们的临床表现,潜在的疾病,治疗,结果及其通过残疾调整生命年(DALYs)的影响。从2007年1月1日至2022年4月20日搜索了五个可用来源。38项研究,包括41个病人,进行了评估。平均年龄为33.6±18.6岁(范围1-68岁),男性28人(68.3%)。中枢神经系统(CNS)传播占主导地位(36/41;87.8%),主要表现为多发性脑脓肿(26/41;63.4%),其次是肺受累(22/41;56.4%)。尖孢孢子菌是最致病的病原体(38/41;92.7%)。总死亡率为51.2%。一半的患者(18/37)在接受适当治疗后治愈,在大多数情况下,伏立康唑单独或与手术或其他抗真菌药物联合使用导致存活。平均生存时间为123±27天。1980-2022年的平均DALYs为46.110±3.318(39.607-52.612)。确诊时间估计为120天,诊断时间和结局之间没有关联.伏立康唑是一种潜在的有效疗法,手术和抗真菌治疗的组合可能导致更有利的结果。早期诊断和适当抗真菌治疗的进展可能有助于降低其死亡率。
    Scedosporium/Lomentospora species exist as saprophytic moulds that can potentially lead to serious infections in patients who have experienced near-drowning incidents. Scedosporium species are distributed across different regions of the world while Lomentospora prolificans has quite a restricted geographic distribution. We aimed to systematically review scedosporiosis cases after near-drowning, their clinical manifestations, underlying diseases, treatments, outcomes and its impact through disability-adjusted life years (DALYs). Five available sources were searched from 1 January 2007, to 20 April 2022. Thirty-eight studies, including 41 patients, were evaluated. Mean age was 33.6 ± 18.6 years (range 1-68), and 28 were male (68.3%). Central nervous system (CNS) dissemination predominated (36/41; 87.8%), presenting mainly as multiple brain abscesses (26/41; 63.4%), followed by lung involvement (22/41; 56.4%). Scedosporium apiospermum species complex was the most causative agent (38/41; 92.7%). Overall mortality was 51.2%. Half of the patients (18/37) were cured after receiving proper treatment, and in most cases, voriconazole alone or in combination with surgery or other antifungals caused survival. The mean survival time was 123 ± 27 days. Mean DALYs in 1980-2022 were 46.110 ± 3.318 (39.607-52.612). Time to diagnosis was estimated to be 120 days, and there was no association between time to diagnosis and outcome. Voriconazole is a potentially effective therapy, and combination of surgery and antifungal treatment may lead to more favourable outcome. Advances in early diagnosis and appropriate antifungal therapy may have contributed to reducing its mortality.
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  • 文章类型: Journal Article
    背景:在冲浪板上设计了一种称为水中复苏(IWR)的技术,以对在水上救援时似乎没有呼吸的人进行通风。尽管IWR在其适用性方面仍然存在不确定性,该技术由国际复苏联络委员会(ILCOR)推荐。因此,这项研究旨在评估IWR在拖曳之前和期间使用救援板的可行性,比较有抢救呼吸尝试和无(SR)的抢救时间和与抢救相关的疲劳水平。
    方法:进行了随机交叉试验:1)用袖珍面罩进行IWR测试,2)常规SR试验。IWR测试是使用LaerdalResusciAnne人体模型(斯塔万格,挪威)。记录三组变量:a)救援时间(以s为单位),b)救援期间的有效通风,和c)感知努力(RPE)评级。
    结果:关注救援时间,性能SR明显快于IWR救援,后者需要61s的时间才能完成救援(Z=-2.805;p=0.005)。RPE技术之间没有发现显着差异(T=-1.890;p=0.095)。在IWR分析中,救生员平均进行了27±12次抢救呼吸。
    结论:IWR在救援板上的应用在救援时和拖曳期间都是可行的。它缩短了复氧时间,但延迟了到达岸上的时间。IWR和SR都导致相似的感知疲劳水平。
    A technique called in-water resuscitation (IWR) was devised on a surfboard to ventilate persons who seemingly did not breathe upon a water rescue. Despite IWR still raises uncertainties regarding its applicability, this technique is recommended by the International Liaison Committee for Resuscitation (ILCOR). Thus, this study aimed to evaluate the feasibility of IWR with a rescue board before and during towing and, to compare rescue times and rescue-associated fatigue levels between rescues with rescue breath attempts and without (SR).
    A randomized crossover pilot test was conducted: 1) IWR test with pocket mask and, 2) Conventional SR test. IWR tests were conducted using a Laerdal ResusciAnne manikin (Stavanger, Norway). Three groups of variables were recorded: a) rescue time (in s), b) effective ventilations during rescue, and c) rating of perceived effort (RPE).
    Focusing on the rescue time, the performance SR was significantly faster than IWR rescue which took 61 s longer to complete the rescue (Z = -2.805; p = 0.005). No significant differences were found between techniques for the RPE (T = -1.890; p = 0.095). In the IWR analysis, lifeguards performed an average of 27 ± 12 rescue breaths.
    The application of IWR on a rescue board is feasible both at the time of rescue and during towing. It shortens the reoxygenation time but delays the arrival time to shore. Both IWR and SR result in similar levels of perceived fatigue.
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  • 文章类型: Journal Article
    目的:溺水事件后儿童的管理基于院前环境中使用的特定干预措施,急诊科(ED)和儿科重症监护病房(PICU)。本文对文献进行了回顾,以绘制和描述医疗保健专业人员在溺水事件后管理儿童时使用的管理和干预措施。特别感兴趣的是地图,根据医疗保健专业人员的不同临床领域或实践领域,综合和描述管理和干预措施。
    方法:对文献进行传统回顾以评估,从32条相关文章中映射和描述信息。使用搜索字符串和布尔运算符AND以及OR搜索了四个电子数据库。所包括的文章都是在2010年至2022年之间以英文发表的,因为它包含了一个时间表,其中包括描述管理和干预措施所必需的当前指南和实践。
    结果:文献中的概念和短语被用作标题,以形成溺水事件后用于管理儿童的干预措施的图片或概述。从文献中提取的信息被绘制在院前管理和干预措施下,ED和PICU以及一个图表显示了这些发现.从文献中可以明显看出,管理和干预措施得到了很好的研究,证据知情和讨论,但没有明确的论据或例子可以将溺水现场的综合管理干预措施与PICU联系起来.冷却和/或复温技术和方法以及终止复苏被认为是干预措施。但没有发现从院前到ED及以后整合的证据.审查还强调了溺水事件后父母没有参与儿童的管理。
    结论:绘制文献能够可视化溺水事件后儿童的管理和干预措施。这些干预措施的整合可以通过让医疗保健从业人员参与进来,形成从溺水现场到PICU的综合管理链接或链条来协作完成。
    OBJECTIVE: Management of children following a drowning incident is based on specific interventions which are used in the prehospital environment, the emergency department (ED) and the Paediatric Intensive Care Unit (PICU). This paper presents a review of the literature to map and describe the management and interventions used by healthcare professionals when managing a child following a drowning incident. Of specific interest was to map, synthesise and describe the management and interventions according to the different clinical domains or practice areas of healthcare professionals.
    METHODS: A traditional review of the literature was performed to appraise, map and describe information from 32 relevant articles. Four electronic databases were searched using search strings and the Boolean operators AND as well as OR. The included articles were all published in English between 2010 and 2022, as it comprised a timeline including current guidelines and practices necessary to describe management and interventions.
    RESULTS: Concepts and phrases from the literature were used as headings to form a picture or overview of the interventions used for managing a child following a drowning incident. Information extracted from the literature was mapped under management and interventions for prehospital, the ED and the PICU and a figure was constructed to display the findings. It was evident from the literature that management and interventions are well researched, evidence-informed and discussed, but no clear arguments or examples could be found to link the interventions for integrated management from the scene of drowning through to the PICU. Cooling and/or rewarming techniques and approaches and termination of resuscitation were found to be discussed as interventions, but no evidence of integration from prehospital to the ED and beyond was found. The review also highlighted the absence of parental involvement in the management of children following a drowning incident.
    CONCLUSIONS: Mapping the literature enables visualisation of management and interventions used for children following a drowning incident. Integration of these interventions can collaboratively be done by involving the healthcare practitioners to form a link or chain for integrated management from the scene of drowning through to the PICU.
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  • 文章类型: Letter
    印度的2例肾移植受者中出现了金沙孢菌感染,从同一位濒临溺水的死者那里获得的.鉴于在实体器官移植受者中与Scedosporium感染相关的死亡风险很大,应彻底重新评估和完善近溺水供体器官移植的安全方案.
    Scedosporium aurianticum infection developed in 2 recipients of kidney transplants in India, acquired from the same deceased near-drowning donor. Given the substantial risk for death associated with Scedosporium infection among solid-organ transplant recipients, safety protocols for organ transplantation from nearly drowned donors should be thoroughly revaluated and refined.
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  • 文章类型: Case Reports
    侵袭性肺曲霉病(IPA)在免疫功能正常的患者中并不常见,但是在非致命溺水后描述了罕见的病例,特别是在受污染的水源中。鉴于亚急性疾病的表现,诊断困难和这种生物的快速进展性质,其死亡率接近50%。临床医生必须依靠基于非培养的生物标志物和影像学来告知早期诊断。目前没有关于近溺水患者霉菌感染的诊断或经验性治疗的建议。我们报告了一名4岁男性浸入粪池后的IPA致命病例。在受污染的水源中几乎淹死后,所有患者都应强烈考虑早期血清生物标志物和经验性伏立康唑。
    溺水存活的儿童在吸入水后会遭受肺部感染。原因通常是住在我们鼻子里的细菌,以及水中的细菌。在肮脏的水中,存在许多不同的细菌。强效抗生素药物通常用于治疗或阻止溺水后感染的发生。霉菌(真菌细菌)也会导致肺部感染,但通常在抗感染能力弱的人群中。我们报告了一例霉菌感染,该霉菌感染从肺部传播到血液和大脑,导致一个先前健康的男孩在动物粪便池塘中溺水后死亡。这些霉菌感染可以缓慢然后迅速传播,因此,除了抗菌药物外,还需要尽早使用抗真菌药物对其进行测试和治疗。
    Invasive pulmonary aspergillosis (IPA) is uncommon in immunocompetent patients, but rare cases have been described after nonfatal drowning, particularly in contaminated water sources. Given subacute disease manifestations, diagnostic difficulties and the rapidly progressive nature of this organism, its mortality rate approaches 50%. Clinicians must rely on nonculture-based biomarkers and imaging to inform early diagnosis. There are currently no recommendations regarding diagnostics or empiric therapy for mold infections in near-drowning patients. We report a fatal case of IPA in a 4-year-old male following submersion in a manure pond. Early serum biomarkers and empiric voriconazole should be strongly considered in all patients after near-drowning in contaminated water sources.
    Children that survive drowning can suffer lung infections after inhaling water. The cause is usually bacteria (germs) that live in our nose, as well as the bacteria in the water itself. In dirty water, many different bacteria are present. Strong antibiotic medicines are usually given to treat or stop infections from happening after drowning. Molds (fungus germs) can also cause lung infections, but usually in people with weak infection-fighting ability. We report a case of a mold infection that spread from the lungs to the blood and brain which led to the death of a previously healthy boy after drowning in a pond of animal waste. These mold infections can be slow and then spread quickly, so testing and treating for it with antifungal medicine in addition to antibacterial medicine needs to be done as early as possible.
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