{Reference Type}: Review
{Title}: Multi-organ involvement caused by Scedosporium apiospermum infection after near drowning: a case report and literature review.
{Author}: Yao Y;Xu Q;Liang W;Ji S;Kosari M;Xu S;Zhu Z;Mao Z;
{Journal}: BMC Neurol
{Volume}: 24
{Issue}: 1
{Year}: 2024 Apr 15
{Factor}: 2.903
{DOI}: 10.1186/s12883-024-03637-9
{Abstract}: <B>BACKGROUND: </B>Scedosporium apiospermum (S. apiospermum) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has a poor prognosis.<BR><B>METHODS: </B>A 37-year-old woman presented with multiple lesions in the lungs, brain, and eyes, shortly after near drowning in a car accident. The primary symptoms were chest tightness, limb weakness, headache, and poor vision in the left eye. S. apiospermum infection was confirmed by metagenomic next-generation sequencing (mNGS) of intracranial abscess drainage fluid, although intracranial metastases were initially considered. After systemic treatment with voriconazole, her symptoms improved significantly; however, she lost vision in her left eye due to delayed diagnosis.<BR><B>CONCLUSIONS: </B>While S. apiospermum infection is rare, it should be considered even in immunocompetent patients. Prompt diagnosis and treatment are essential. Voriconazole may be an effective treatment option.