未经评估:噪声性听力损失是听力损害和职业病的最普遍原因之一。尽管多种因素导致噪声引起的听力损失,预防和保护战略仍然有限。在过去的十年中,研究使用了抗氧化剂,尤其是N-乙酰半胱氨酸,以防止噪声引起的听力损失。因此,这项随机对照试验的系统评价和荟萃分析评价了N-乙酰半胱氨酸预防噪声性听力损失的效果.
UNASSIGNED:本系统综述和荟萃分析包括来自Cochrane图书馆的相关研究,EMBASE,PubMed,ScienceDirect,Scopus,和WebofScience使用相关术语。该研究仅包括荟萃分析中的随机对照试验,并通过使用Cochrane偏差风险工具评估已确定的随机对照试验的质量。两位作者提取并计算了有关特征和听力阈值的数据。结果以加权平均差(WMD)表示,具有95%置信区间(CI)。
UNASSIGNED:这项研究确定了五项随机对照试验,将1,115名患者随机分为N-乙酰半胱氨酸组和对照组。荟萃分析表明,在0至4kHz(WMD=-3.39,95%CI:-6.56至-0.22)和0至6kHz(MD=-3.49,95%CI:-6.57至-0.41)亚组中,N-乙酰半胱氨酸对听力阈值变化具有更大的保护作用。
UNASSIGNED:本综述和荟萃分析建议,N-乙酰半胱氨酸可作为噪声引起的听力损失的保护性治疗的一种选择。尽管如此,更大规模的随机对照试验是进一步调查和验证的必要条件.
UNASSIGNED: Noise-induced hearing loss is one of the most prevalent causes of hearing impairment and occupational diseases. Although multiple factors lead to noise-induced hearing loss, prevention and protection strategies remain limited. Studies in the past decade have employed antioxidants, especially N-acetyl-cysteine, to prevent noise-induced hearing loss. Therefore, this systematic review and meta-analysis of randomized controlled trials evaluated the effect of N-acetyl-cysteine on the prevention of noise-induced hearing loss.
UNASSIGNED: This systematic review and meta-analysis included relevant studies from the Cochrane Library, EMBASE, PubMed, ScienceDirect, Scopus, and Web of Science by using related terms. The study only included randomized controlled trials in meta-analyses and assessed the quality of the identified randomized controlled trials by using the Cochrane Risk of Bias tool. Two authors extracted and calculated data on characteristics and hearing threshold. The results are presented as weighted mean difference (WMD) with 95% confidence interval (CI).
UNASSIGNED: This study identified five randomized controlled trials that randomized 1,115 patients into N-acetyl-cysteine and control groups. The meta-analysis evidenced that N-acetyl-cysteine has greater protective effects against hearing threshold shifts than the control in the 0 to 4 kHz (WMD = -3.39, 95% CI: -6.56 to -0.22) and 0 to 6 kHz (MD = -3.49, 95% CI: -6.57 to -0.41) subgroups.
UNASSIGNED: The present review and meta-analysis recommends that N-acetyl-cysteine may be considered as an option for protective therapy for noise-induced hearing loss. Nonetheless, larger randomized controlled trials are requisite for further investigation and verification.