COVID-19大流行,它出现在2020年初,对全球卫生产生了深远而持久的影响,导致700多万人死亡和持续的挑战。除了严重的担忧,越来越多的人关注COVID-19幸存者的长期健康后果,有记录的心血管异常病例,肝脏紊乱,肺部并发症,肾脏问题,和明显的认知缺陷。最近的研究调查了长期暴露于鼠肝炎病毒-1(MHV-1)后各种器官的生理变化,冠状病毒,在小鼠模型中。一个重要的发现涉及对胃肠道的影响,一个以前关于COVID-19长期影响的研究不足的领域。这项研究揭示了MHV-1感染后急性和延长期肠道中的重要观察结果,这与暴露于SARS-CoV-2后在人类中看到的特定变化平行。我们的研究调查了小鼠模型中MHV-1感染后小肠的组织病理学改变,揭示出显着的变化,让人联想到炎症性肠病(IBD),乳糜泻.值得注意的发现包括粘膜炎症,淋巴增生,杯状细胞增生,免疫细胞浸润,反映IBD中观察到的病理特征。此外,MHV-1感染诱导绒毛萎缩,改变上皮完整性,和类似于乳糜泻和IBD的炎症反应。SPIKENET(SPK)治疗可有效减轻MHV-1感染引起的肠道损伤,恢复组织结构和改善炎症反应。此外,对长COVID的调查揭示了复杂的炎症特征,强调SPK调节肠道反应和恢复组织稳态的潜力。了解这些组织病理学改变为COVID引起的胃肠道并发症的发病机制提供了有价值的见解,并为靶向治疗策略的发展提供了信息。
The COVID-19 pandemic, which emerged in early 2020, has had a profound and lasting impact on global health, resulting in over 7.0 million deaths and persistent challenges. In addition to acute concerns, there is growing attention being given to the long COVID health consequences for survivors of COVID-19 with documented cases of cardiovascular abnormalities, liver disturbances, lung complications, kidney issues, and noticeable cognitive deficits. Recent studies have investigated the physiological changes in various organs following prolonged exposure to murine hepatitis virus-1 (MHV-1), a coronavirus, in mouse models. One significant finding relates to the effects on the gastrointestinal tract, an area previously understudied regarding the long-lasting effects of COVID-19. This research sheds light on important observations in the intestines during both the acute and the prolonged phases following MHV-1 infection, which parallel specific changes seen in humans after exposure to SARS-CoV-2. Our study investigates the histopathological alterations in the small intestine following MHV-1 infection in murine models, revealing significant changes reminiscent of inflammatory bowel disease (IBD), celiac disease. Notable findings include mucosal inflammation, lymphoid hyperplasia, goblet cell hyperplasia, and immune cell infiltration, mirroring pathological features observed in IBD. Additionally, MHV-1 infection induces villous atrophy, altered epithelial integrity, and inflammatory responses akin to celiac disease and IBD. SPIKENET (SPK) treatment effectively mitigates intestinal damage caused by MHV-1 infection, restoring tissue architecture and ameliorating inflammatory responses. Furthermore, investigation into long COVID reveals intricate inflammatory profiles, highlighting the potential of SPK to modulate intestinal responses and restore tissue homeostasis. Understanding these histopathological alterations provides valuable insights into the pathogenesis of COVID-induced gastrointestinal complications and informs the development of targeted therapeutic strategies.