发现靶向 SARS - CoV - 2 Mac1 并抑制冠状病毒复制的 2 - 酰胺 - 3 - 甲酯噻吩 ,验证 Mac1 作为抗病毒靶标。
Mesh : Antiviral Agents / pharmacology chemistry chemical synthesis Thiophenes / pharmacology chemistry chemical synthesis Virus Replication / drug effects Humans SARS-CoV-2 / drug effects Animals Drug Discovery Mice Crystallography, X-Ray COVID-19 Drug Treatment Structure-Activity Relationship Murine hepatitis virus / drug effects
来 源:
DOI:10.1021/acs.jmedchem.3c02451
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