■如今,由于各种原因,人们受到辐射,包括自然,诊断,职业或意外暴露。高水平暴露于电离辐射对人体可能是致命的。用于防止辐射引起的损害的合成药物本质上是有毒的。最近,由于其作用机制,正在筛选草药作为替代药物。藤黄(G.印度)是传统的药用植物之一,含有具有多种药用特性的植物化学物质。
■在这项研究中,观察到G.in草提取物对3Gray(Gy)γ辐射诱导的人外周血淋巴细胞损伤的调节作用。在照射后0小时,将各种浓度范围为1至25μg/mL的India提取物添加到血液中。根据标准程序进行染色体畸变(CA)和细胞松弛素B阻断的微核细胞周期(CBMN)测定。
■本研究观察了藤黄果皮提取物(GIFRE)对CA和MN形成的放射调节作用。GIFRE的治疗不影响有丝分裂指数。双中心的正抑制百分比,除一例外,观察到总染色体畸变和微核。
■由于藤黄提取物的各种性质,它使其成为测试其放射调节作用的潜在候选者。根据这项初步研究中观察到的结果,它可以作为放射调节剂。GIFRE的放射调节作用可能会成为当前药物的潜在草药替代品。然而,这项研究的结果需要在更大的样本量上进行验证。
UNASSIGNED: Nowadays people are exposed to radiation due to various reasons, including natural, diagnostic, occupational or accidental exposure. High level of exposure to ionizing radiation can be fatal to human body. Synthetic drugs used to prevent radiation-induced damage are toxic in nature. Recently, Herbal drugs are being screened as an alternative due to their mechanism of action. Garcinia indica (G. indica) is one of the traditional medicinal plant which contains phytochemicals having several medicinal properties.
UNASSIGNED: In this study, G. indica extract was observed for its modulatory effect against 3 Gray (Gy) gamma radiation-induced damages in human peripheral blood lymphocytes. Various concentrations of G. indica extract ranging from 1 to 25 µg/mL was added to the blood post irradiation at 0 hr. Chromosomal aberration (CA) and Cytochalasin B blocked
Micronuclei Cytome (CBMN) Assay were performed as per standard procedure.
UNASSIGNED: Radiomodulatory effect of Garcinia indica fruit rind extract (GIFRE) on CA and MN formation was observed in this study. Treatment of GIFRE did not affect the mitotic index. Positive inhibition percentages for dicentrics, total chromosomal aberrations and
micronuclei were observed except for one instance.
UNASSIGNED: Owing to the various properties of Garcinia extracts, it makes it a potential candidate to be tested for its radiomodulatory effect. Based on the results observed in this preliminary study, it could act as a radiomodulatory agent. Radiomodulatory effect of GIFRE could possibly serve it as a potential herbal medicinal alternative to current drugs. However, results of this study need to be validated on larger sample size.