PDF(Pubmed)
Abstract：
UNASSIGNED: Coal mining is a vital sector in Colombia, contributing significantly to the nation\'s economy and the development of its regions. However, despite its importance, it has led to a gradual decline in the health of mine workers and nearby residents. While the adverse health effects of open-pit coal mining on exposed individuals have been well-documented in Colombia and globally, studies investigating genetic damage in underground coal miners are lacking.
UNASSIGNED: The aim of our study was to evaluate chromosomal and genotoxic damage, in peripheral blood samples from a group of underground coal miners and residents of areas exposed to coal, in the town of Samacá, Boyacá-Colombia, and in a group of unexposed individuals by using banding and molecular cytogenetic techniques, as well as cytokinesis block micronucleus assays.
UNASSIGNED: Our results suggest that occupational exposure to coal induces chromosomal and genotoxic damage in somatic cells of underground coal miners. Chromosomal and genotoxic damage is an important step in carcinogenesis and the development of many other diseases. Our findings provide valuable insights into the effects of coal dust exposure on chromosomal integrity and genetic stability.
UNASSIGNED: Our pilot study suggests that occupational exposure to coal induces chromosomal damage in underground coal miners, highlighting the importance of validating these findings with a larger sample size. Our results highlight the need to implement prevention and protection measures, as well as educational programs for underground coal miners. Characterizing and estimating exposure risks are extremely important for the safety of people exposed occupationally and environmentally to coal and its derivatives.
UNASSIGNED: The aim of our study was to evaluate chromosomal and genotoxic damage, in peripheral blood samples from a group of underground coal miners and residents of areas exposed to coal, in the town of Samacá, Boyacá-Colombia, and in a group of unexposed individuals by using banding and molecular cytogenetic techniques, as well as cytokinesis block micronucleus assays.
UNASSIGNED: Our results suggest that occupational exposure to coal induces chromosomal and genotoxic damage in somatic cells of underground coal miners. Chromosomal and genotoxic damage is an important step in carcinogenesis and the development of many other diseases. Our findings provide valuable insights into the effects of coal dust exposure on chromosomal integrity and genetic stability.
UNASSIGNED: Our pilot study suggests that occupational exposure to coal induces chromosomal damage in underground coal miners, highlighting the importance of validating these findings with a larger sample size. Our results highlight the need to implement prevention and protection measures, as well as educational programs for underground coal miners. Characterizing and estimating exposure risks are extremely important for the safety of people exposed occupationally and environmentally to coal and its derivatives.
摘要：
■煤炭开采是哥伦比亚的一个重要部门，为国家经济和地区发展做出重大贡献。然而,尽管它很重要,这导致矿工和附近居民的健康状况逐渐下降。虽然在哥伦比亚和全球，露天煤矿开采对暴露个体的不利健康影响已得到充分记录，缺乏调查地下煤矿工人遗传损伤的研究。
■我们研究的目的是评估染色体和基因毒性损伤，在一组地下煤矿工人和暴露于煤炭地区的居民的外周血样本中，在萨马卡镇，Boyacá-哥伦比亚,通过使用条带和分子细胞遗传学技术，在一组未暴露的个体中，以及胞质分裂阻断微核试验。
■我们的结果表明，职业暴露于煤炭会引起地下煤矿工人体细胞的染色体和遗传毒性损伤。染色体和基因毒性损伤是癌症发生和许多其他疾病发展的重要步骤。我们的发现为煤尘暴露对染色体完整性和遗传稳定性的影响提供了有价值的见解。
■我们的初步研究表明，职业性接触煤炭会导致地下煤矿工人染色体受损，强调用更大的样本量验证这些发现的重要性。我们的结果强调了实施预防和保护措施的必要性，以及地下煤矿工人的教育计划。表征和估计暴露风险对于在职业和环境中暴露于煤炭及其衍生物的人们的安全极为重要。
■我们研究的目的是评估染色体和基因毒性损伤，在一组地下煤矿工人和暴露于煤炭地区的居民的外周血样本中，在萨马卡镇，Boyacá-哥伦比亚,通过使用条带和分子细胞遗传学技术，在一组未暴露的个体中，以及胞质分裂阻断微核试验。
■我们的结果表明，职业暴露于煤炭会引起地下煤矿工人体细胞的染色体和遗传毒性损伤。染色体和基因毒性损伤是癌症发生和许多其他疾病发展的重要步骤。我们的发现为煤尘暴露对染色体完整性和遗传稳定性的影响提供了有价值的见解。
■我们的初步研究表明，职业性接触煤炭会导致地下煤矿工人染色体受损，强调用更大的样本量验证这些发现的重要性。我们的结果强调了实施预防和保护措施的必要性，以及地下煤矿工人的教育计划。表征和估计暴露风险对于在职业和环境中暴露于煤炭及其衍生物的人们的安全极为重要。
