背景:普通的成年美国人消耗的含硫氨基酸(SAA)的水平远高于估计的平均需求量(EAR),最近的临床前数据表明,较高的SAA摄入量可能与多种衰老相关的慢性疾病有关。然而,关于SAA摄入量与人类慢性疾病风险之间关系的数据很少。这项研究的目的是检查SAA的消耗与心脏代谢疾病的危险因素之间的关联。
方法:样本包括第三次全国考试和营养健康调查(NHANESIII)研究(1988-1994)的11,576名成年参与者。主要结果是心脏代谢疾病风险评分(基于血液胆固醇的复合危险因素,甘油三酯,HDL,C反应蛋白(CRP),尿酸,葡萄糖,血尿素氮(BUN),糖化血红蛋白,胰岛素,和eGFR)。按能量调整后的总SAA的五分之一进行风险评分的组差异,蛋氨酸(Met),和半胱氨酸(Cys)摄入量在调整年龄后通过多元线性回归确定,性别,BMI,吸烟,酒精摄入量,和饮食因素。我们进一步检查了SAA摄入量与个体危险因素之间的关联。
结果:平均SAA消耗量比EAR高2.5倍。经过多变量调整后,SAA的摄入量较高,Met,和Cys与复合心脏代谢疾病风险评分的显着增加相关,独立于蛋白质摄入,和几个单独的危险因素,包括血清胆固醇,葡萄糖,尿酸,BUN,胰岛素和糖化血红蛋白(p<0.01)。
结论:总体而言,我们的研究结果表明,降低SAA(接近EAR)的饮食与降低心脏代谢疾病的风险相关.低SAA饮食模式依赖于植物来源的蛋白质来源,而不是肉类来源的食物。鉴于大多数成年人的SAA摄入量高,我们的研究结果可能对慢性病预防具有重要的公共卫生意义.
背景:这项研究没有任何资助。
BACKGROUND: An average adult American consumes sulfur amino acids (SAA) at levels far above the Estimated Average Requirement (EAR) and recent preclinical data suggest that higher levels of SAA intake may be associated with a variety of aging-related chronic diseases. However, there are little data regarding the relationship between SAA intake and chronic disease risk in humans. The aim of this study was to examine the associations between consumption of SAA and risk factors for cardiometabolic diseases.
METHODS: The sample included 11,576 adult participants of the Third National Examination and Nutritional Health Survey (NHANES III) Study (1988-1994). The primary outcome was cardiometabolic disease risk score (composite risk factor based on blood cholesterol, triglycerides, HDL, C-reactive protein (CRP), uric acid, glucose, blood urea nitrogen (BUN), glycated hemoglobin, insulin, and eGFR). Group differences in risk score by quintiles of energy-adjusted total SAA, methionine (Met), and cysteine (Cys) intake were determined by multiple linear regression after adjusting for age, sex, BMI, smoking, alcohol intake, and dietary factors. We further examined for associations between SAA intake and individual risk factors.
RESULTS: Mean SAA consumption was > 2.5-fold higher than the EAR. After multivariable adjustment, higher intake of SAA, Met, and Cys were associated with significant increases in composite cardiometabolic disease risk scores, independent of protein intake, and with several individual risk factors including serum cholesterol, glucose, uric acid, BUN, and insulin and glycated hemoglobin (p < 0.01).
CONCLUSIONS: Overall, our findings suggest that diets lower in SAA (close to the EAR) are associated with reduced risk for cardiometabolic diseases. Low SAA dietary patterns rely on plant-derived protein sources over meat derived foods. Given the high intake of SAA among most adults, our findings may have important public health implications for chronic disease prevention.
BACKGROUND: This study does not have any funding.