短链脂肪酸通过诱导人类结直肠腺癌细胞中活性氧的产生来重新编程代谢谱。
关键词: 1H–13C HMBC, 1H–13C Heteronuclear Multiple Bond Correlation Spectroscopy 1H–13C HSQC, 1H–13C Heteronuclear Single Quantum Coherence Spectroscopy 1H–1H COSY, 1H–1H Correlation Spectroscopy 1H–1H TOCSY, 1H–1H Total Correlation Spectroscopy ADP, Adenosine diphosphate AMP, Adenosine monophosphate ATP, Adenosine triphosphate Ace, Acetate Ach, Acetylcholine Ala, Alanine CRC, Colorectal Cancer Caco-2, Human Colon Adenocarcinoma Cho, Choline CoA, Coenzyme A Cre, Creatine DCFH-DA, Dichloro-Dihydro-Fluorescein Diacetate DEGs, Differentially Expressed Genes DMEM, Dulbecco's Modified Eagle Medium DMG, Dimethylglycine DNA, Deoxyribonucleic Acid EP, Eppendorf FA, Formate FDR, False Discovery Rate Fru, Fructose Fum, Fumaric acid GLS, Glutaminase GSEA, Gene Set Enrichment Analysis GSH, Glutathione Gal-1-P, Galactose-1-phosphate Glc, Glucose Gln, Glutamine Glu, Glutamate Gly, Glycine HCT116, Human Colorectal Carcinoma Cell Line HEK, Human Embryonic Kidney cells HT29, Human Colorectal Adenocarcinoma Cell Line with Epithelial Morphology His, Histidine Ile, Isoleucine J-Res, J-resolved Spectroscopy LDH, Lactate Dehydrogenase Lac, Lactate Leu, Leucine Lys, Lysine MCF-7, Human Breast Cancer Cell Line with Estrogen MCT, Monocarboxylate Transporters Met, Methionine MetS, Metabolic Syndrome Mitochondrial function NAD+, Nicotinamide adenine dinucleotide NAG, N-Acetyl-L-Glutamine NMR, Nuclear Magnetic Resonance NMR-based Metabolomics NOESY, Nuclear Overhauser Effect Spectroscopy O-PLS-DA, Orthogonal Projection to the Latent Structures Discriminant Analysis PA, Pantothenate PC, Phosphocholine PCA, Principal Component Analysis PDC, Pyruvate Decarboxylase PDK, Pyruvate Dehydrogenase Kinase PKC, Protein Kinase C PPP, Pentose Phosphate Pathway Phe, Phenylalanine Pyr, Pyruvate RNA, Ribonucleic Acid ROS, Reactive Oxygen Species RPKM, Reads per Kilobase of Transcript per Million Reads Mapped Reactive oxygen species SCFAs, Short Chain Fatty Acids SLC, Solute-Carrier Genes Short-chain fatty acids Suc, Succinate T2DM, Type 2 Diabetes TCA, Tricarboxylic Acid Tau, Taurine Thr, Threonine Transcriptomics Tyr, Tyrosine UDP, Uridine 5′-diphosphate UDP-GLC, UDP Glucose UDPG, UDP Glucuronate UDPGs, UDP Glucose and UDP Glucuronate UMP, Uridine 5′-monophosphate Val, Valine WST-1, Water-Soluble Tetrazolium salts dDNP, dissolution Dynamic Nuclear Polarization qRT-PCR, Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction α-KIV, α-Keto-isovalerate α-KMV, α-keto-β-methyl-valerate
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DOI:10.1016/j.csbj.2023.02.022
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