■根据观测研究,偏头痛可能增加梅尼埃病(MD)的风险。两人没有,然而,被证明是因果关系的。
■使用孟德尔随机(MR)分析,我们旨在评估偏头痛和MD之间的任何潜在因果关系.我们从涉及欧洲个体的大规模全基因组关联研究(GWAS)中提取了单核苷酸多态性(SNP),专注于偏头痛和MD。用于评估效果估计的主要技术是方差逆加权(IVW)。为了评估异质性和多效性,敏感性分析使用加权中位数进行,MR-Egger,简单模式,加权模式,MR-PRESSO
■MD的遗传易感性与偏头痛之间没有明显的因果关系。在随机效应IVW方法中,偏头痛剂量并未增加MD的患病率(OR=0.551,P=0.825)。额外加权中位数分析(OR=0.674,P=0.909),MR-Egger(OR=0.068,P=0.806),简单模式(OR=0.170,P=0.737),和加权模式(OR=0.219,P=0.760)均显示出基本一致的结果。在随机效应IVW方法中,MD剂量不会增加偏头痛的患病率(OR=0.999,P=0.020)。额外加权中位数分析(OR=0.999,P=0.909),MR-Egger(OR=0.999,P=0.806),简单模式(OR=0.999,P=0.737),和加权模式(OR=1.000,P=0.760)。
■这项孟德尔随机研究提供了偶然的证据,证明偏头痛不是MD的危险因素,并且MD也不是偏头痛的危险因素。
UNASSIGNED: According to observational research, migraine may increase the risk of Meniere\'s disease (MD). The two have not, however, been proven to be causally related.
UNASSIGNED: Using Mendelian random (MR) analysis, we aimed to evaluate any potential causal relationship between migraine and MD. We extracted single-nucleotide polymorphisms (SNPs) from large-scale genome-wide association studies (GWAS) involving European individuals, focusing on migraine and MD. The main technique used to evaluate effect estimates was inverse-variance weighting (IVW). To assess heterogeneity and pleiotropy, sensitivity analyses were carried out using weighted median, MR-Egger, simple mode, weighted mode, and MR-PRESSO.
UNASSIGNED: There was no discernible causative link between genetic vulnerability to MD and migraine. The migraine dose not increase the prevalence of MD in the random-effects IVW method (OR = 0.551, P = 0.825). The extra weighted median analysis (OR = 0.674, P = 0.909), MR-Egger (OR = 0.068, P = 0.806), Simple mode (OR = 0.170, P = 0.737), and Weighted mode (OR = 0.219, P= 0.760) all showed largely consistent results. The MD dose not increase the prevalence of migraine in the random-effects IVW method (OR = 0.999, P = 0.020). The extra weighted median analysis (OR = 0.999, P = 0.909), MR-Egger (OR = 0.999, P = 0.806), Simple mode (OR = 0.999, P = 0.737), and Weighted mode (OR = 1.000, P = 0.760).
UNASSIGNED: This Mendelian randomization study provides casual evidence that migraine is not a risk factor for MD and MD is also not a risk factor for migraine.