关键词: Meniere’s disease endolymphatic hydrops otolith saccular dysfunction sound stimulation

Mesh : Humans Meniere Disease / therapy physiopathology Middle Aged Male Female Vestibular Evoked Myogenic Potentials / physiology Adult Acoustic Stimulation / methods Aged Saccule and Utricle / physiopathology Endolymphatic Hydrops / therapy physiopathology

来  源:   DOI:10.1080/00016489.2024.2363462

Abstract:
UNASSIGNED: Although various medical remedies have been attempted to alleviate the symptoms of Meniere\'s disease (MD), the risk-benefit ratios of these various treatments remain debatable.
UNASSIGNED: We investigated the efficacy of sound stimulation of 100 Hz for treating vestibular dysfunction in patients with Meniere\'s disease (MD).
UNASSIGNED: Patients with definitive MD with intractable vestibular symptoms and endolymphatic hydrops (EH) in the inner ear were evaluated. The experimental group received sound stimulation of 75 dB at a frequency of 100 Hz for 5 min, and the control group received sound stimulation of 75 dB at a frequency of 250 Hz for 5 min. Cervical vestibular-evoked myogenic potentials (cVEMPs) were measured before and after each sound stimulation, and the results of the clinical tests were compared between the two patient groups.
UNASSIGNED: Significant increases in cVEMP amplitudes were observed after sound stimulation of 100 Hz in ears with vestibular endolymphatic hydrops, although no such improvement was observed in the control group.
UNASSIGNED: Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cVEMP amplitude in patients with definitive MD. Adequate sound stimulation might be a new method for treating vestibular dysfunction associated with MD.
摘要:
尽管已经尝试了各种医疗疗法来减轻梅尼埃病(MD)的症状,这些不同治疗方法的风险-收益比仍有争议.
我们研究了100Hz声音刺激治疗梅尼埃病(MD)患者前庭功能障碍的疗效。
对患有难治性前庭症状和内耳内淋巴积水(EH)的明确MD患者进行了评估。实验组在100Hz的频率下接受75dB的声音刺激,持续5min,对照组在250Hz的频率下接受75dB的声音刺激,持续5分钟。在每次声音刺激之前和之后测量宫颈前庭诱发的肌源性电位(cVEMPs),并比较两组患者的临床检查结果。
在有前庭内淋巴积水的耳朵中,声音刺激100Hz后,观察到cVEMP振幅显着增加,尽管对照组没有观察到这种改善。
在100Hz频率下的75dB声音刺激导致明确MD患者的cVEMP振幅改善。适当的声音刺激可能是治疗与MD相关的前庭功能障碍的新方法。
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