■中链脂肪酸(MCFA)在预防或改善肥胖方面引起了极大的关注,这是生活方式相关疾病的公认风险因素。中链和长链甘油三酯(MLCT)有望改善摄入的长链甘油三酯(LCT)的代谢。然而,以前的研究报告了不同的结果。在这项研究中,评估了摄入MLCTs对LCTs代谢的影响,并将其与摄入菜籽油(对照油)进行了比较。
■随机,双盲,安慰剂对照交叉研究是在体重指数在25kg/m2以下的久坐参与者中进行的.30名参与者被要求摄入14克MLCT或对照油4周。通过测量碳-13(13C)标记的LCT的降解释放的同位素标记的二氧化碳来评估摄入的LCT的代谢。
■与对照油相比,摄入MLCTs显著增强了摄入的LCTs的代谢。
■这项研究的结果表明,摄入MLCTs可能通过激活肝脏线粒体中的β-氧化来增强膳食LCTs的代谢,这可能会增加摄入的长链脂肪酸(LCFAs)的代谢动力学。
■https://center6。乌明。AC.jp/cgi-open-bin/ctr/ctr_view。cgi?recptno=R000053101,标识符:UMIN000046604。
UNASSIGNED: Medium-chain fatty acids (MCFAs) have attracted considerable attention for preventing or improving obesity, which is a recognized risk factor for lifestyle-related diseases. Medium- and long-chain triglycerides (MLCTs) are expected to improve the metabolism of ingested long-chain triglycerides (LCTs). However, previous studies have reported mixed results. In this study, the effect of ingestion of MLCTs was evaluated on the metabolism of LCTs and compared to the ingestion of rapeseed oil (control oil).
UNASSIGNED: A randomized, double-blind, placebo-controlled crossover study was performed among sedentary participants with BMIs ranging from 25 below 30 kg/m2. Thirty participants were asked to ingest either 14 g of MLCTs or a control oil for 4 weeks. The metabolism of ingested LCTs was evaluated by measuring isotopically labeled carbon dioxide released by the degradation of carbon-13 (13C)-labeled LCTs.
UNASSIGNED: Ingestion of MLCTs markedly enhanced the metabolism of ingested LCTs by comparison to the control oil.
UNASSIGNED: The findings of this study suggest that ingestion of MLCTs may enhance the metabolism of dietary LCTs through activation of β-oxidation in liver mitochondria, which may increase the metabolic kinetics of ingested long-chain fatty acid (LCFAs).
UNASSIGNED: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000053101, identifier: UMIN000046604.