■最近的研究已经解决了长链非编码RNA(lnc-RNA)的可能作用,转移相关肺腺癌转录本1(MALAT1),和牛磺酸上调基因1(TUG1),调节肥胖相关代谢异常的潜在机制。然而,研究是有限和矛盾的。因此,我们试图研究肥胖和超重女性中这两种lnc-RNA的转录水平与代谢综合征(MetS)相关参数的关系.
■这项横断面研究是对342名肥胖和超重的女性进行的。我们进行了包括人体测量的评估,身体成分分析,空腹血糖(FBS)水平,脂质分析,胰岛素水平,HOMA-IR指数,和肝脏酶谱.定量实时聚合酶链反应(PCR)用于评估MALAT1和TUG1的转录水平。此外,使用147个问题的半定量食物频率问卷(FFQ)和国际身体活动问卷(IPAQ)来评估食物摄入量和身体活动,分别。
■FBS与MALAT1转录水平之间存在显着关联(β:0.382;95%CI:0.124,0.640;P=0.004)。此外,甘油三酯(TG)与MALAT1转录水平之间存在显著相关性(β:4.767;95%CI:2.803,6.731;P<0.0001)。在调整了年龄之后,BMI,能量摄入,和身体活动,高密度脂蛋白胆固醇(HDL-c)与MALAT1转录水平呈负相关(β:-0.325;95%CI:-0.644,-0.006;P=0.046).
■我们的研究结果表明MALAT1mRNA水平与MetS相关参数呈正相关,包括FBG,TG,HDL,超重和肥胖女性的收缩压。然而,需要大量的前瞻性研究来进一步确立这一概念。
■在线版本包含补充材料,可在10.1007/s40200-023-01367-2获得。
UNASSIGNED: Recent studies have addressed the possible role of long non-coding RNAs (lnc-RNAs), Metastasis-Associated Lung Adenocarcinoma Transcript 1 (
MALAT1), and Taurine Upregulated Gene 1 (TUG1), in modulating the underlying mechanisms of obesity-related metabolic abnormalities. However, studies are limited and contradictory. Hence, we sought to investigate the relationship of the transcript level of these two lnc-RNAs with metabolic syndrome (MetS)-related parameters in women with obesity and overweight.
UNASSIGNED: This cross-sectional study was conducted on 342 women with obese and overweight. We conducted assessments encompassing anthropometric measurements, body composition analysis, fasting blood sugar (FBS) levels, lipid profile analysis, insulin levels, HOMA-IR index, and liver enzyme profiling. A quantitative real-time polymerase chain reaction (PCR) was used to evaluate transcript levels of
MALAT1 and TUG1. Also, a 147-question semi-quantitative food frequency questionnaire (FFQ) and the International Physical Activity Questionnaire (IPAQ) were used to evaluate food intake and physical activity, respectively.
UNASSIGNED: There was a significant association between FBS and
MALAT1 transcript level (β: 0.382; 95% CI: 0.124, 0.640; P = 0.004). Also, there was a significant association between triglyceride (TG) and
MALAT1 transcript level (β: 4.767; 95% CI: 2.803, 6.731; P < 0.0001). After adjusting for age, BMI, energy intake, and physical activity, an inverse significant association was observed between high-density lipoprotein cholesterol (HDL-c) and MALAT1 transcript level (β: -0.325; 95% CI: -0.644, -0.006; P = 0.046).
UNASSIGNED: Our findings indicated positive associations between mRNA levels of
MALAT1 and MetS-related parameters, including FBG, TG, HDL, and systolic blood pressure in overweight and obese women. However, large prospective studies are needed to further establish this concept.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s40200-023-01367-2.