Abstract：
Dermatologic disorders, affecting the integumentary system, involve diverse molecular mechanisms such as cell proliferation, apoptosis, inflammation and immune responses. Long noncoding RNAs, particularly Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1), are crucial regulators of gene expression. MALAT1 influences inflammatory responses, immune cell function and signaling pathways, impacting various physiological and pathological processes, including dermatologic disorders. Dysregulation of MALAT1 is observed in skin conditions like psoriasis, atopic dermatitis and systemic lupus erythematosus. However, its precise role remains unclear. This review consolidates knowledge on MALAT1\'s impact on skin biology and pathology, emphasizing its potential diagnostic and therapeutic implications in dermatologic conditions.
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摘要：
皮肤病,影响外皮系统，涉及多种分子机制，如细胞增殖，凋亡，炎症和免疫反应。长链非编码RNA，特别是转移相关的肺腺癌转录本1（MALAT1），是基因表达的关键调节因子。MALAT1影响炎症反应，免疫细胞功能和信号通路，影响各种生理和病理过程，包括皮肤病。在牛皮癣等皮肤病中观察到MALAT1的失调，特应性皮炎和系统性红斑狼疮。然而,其确切作用尚不清楚。这篇综述巩固了MALAT1对皮肤生物学和病理学影响的知识，强调其在皮肤病中的潜在诊断和治疗意义。
[方框：见正文]。
[方框：见正文]。
