本研究旨在评估Alhagi蜂蜜小分子糖(AHAS)对Hu羔羊的影响。因此,在这项研究中,AHAS低剂量(AHAS-L,每天200mg/kg),AHAS中等剂量(AHAS-M,400mg/kg/天),和AHAS高剂量(AHAS-H,每天800mg/kg)给Hu羔羊施用,以研究AHAS对生长性能的调节作用,氧化指数,免疫系统增强,和肠道微生物群。结果表明,AHAS-H组羔羊平均日增重显著增加,和生长性能与对照组相比(p<0.05)。此外,补充AHAS-H导致血清抗氧化酶水平升高(SOD,GSH-Px,和T-AOC),血清抗体(IgA,IgG,和IgM),和细胞因子(IL-4,10,17,IFN-γ,和TNF-α)与对照组相比(p<0.05)。此外,它增加了有益菌的数量和丰富度,如鞘氨醇单胞菌,Ralstonia,和黄杆菌,激活各种代谢途径,促进各种短链脂肪酸的产生。总之,我们的发现强调了AHAS-H治疗通过改善肠道功能增强羔羊肠道健康的潜力,豁免权,和相关的代谢途径。因此,这些结果表明,AHAS作为优化羔羊生长性能和肠道健康的有价值的干预措施具有很好的潜力。
The present study was designed to assess the impact of Alhagi honey small-molecule sugars (AHAS) on Hu lambs. Therefore, in this study, AHAS low-dose (AHAS-L, 200 mg/ kg per day), AHAS medium-dose (AHAS-M, 400 mg/kg per day), and AHAS high-dose (AHAS-H, 800 mg/kg per day) were administered to Hu lambs to investigate the regulatory effects of AHAS on growth performance, oxidation index, immune system enhancement, and intestinal microbiota. The results showed that lambs in the AHAS-H group exhibited significantly increased in average daily weight gain, and growth performance compared to those in the control group (p < 0.05). Moreover, AHAS-H supplementation resulted in increased levels of serum antioxidant enzymes (SOD, GSH-Px, and T-AOC), serum antibodies (IgA, IgG, and IgM), and cytokines (IL-4, 10,17, IFN-γ, and TNF-α) compared with the control group (p < 0.05). Additionally, it increased the quantity and richness of beneficial bacteria at such as Sphingomonas, Ralstonia, and Flavobacterium, activating various metabolic pathways and promoting the production of various short-chain fatty acids. In summary, our findings highlight the potential of AHAS-H treatment in enhancing intestinal health of lambs by improving intestinal function, immunity, and related metabolic pathways. Consequently, these results suggest that AHAS holds promising potential as a valuable intervention for optimizing growth performance and intestinal health in lambs.