我们旨在使用韩国国家健康与营养调查(KNHANES)的数据评估每日饮食钙摄入量与绝经后妇女心血管疾病(CVD)风险之间的关系。这项横断面研究包括12,348名年龄在45-70岁之间的自然更年期女性。根据每日膳食钙摄入量将它们分为三组:<400毫克,400-800毫克,>800毫克。心血管疾病的风险,中风,心绞痛,并对各组进行心肌梗死评估。Further,我们根据绝经后持续时间进行亚组分析(≤10vs.>绝经后10年)。我们进行了逻辑回归分析,调整了年龄,更年期年龄,收入,市区,教育,胰岛素的使用,身体质量指数,高血压,糖尿病,血脂异常,高酒精摄入量,吸烟,锻炼,口服避孕药的使用,和激素疗法的使用。在总人口和≤10年绝经后亚组中,钙摄入水平与CVD风险无显著相关。然而,在>10年绝经后亚组,每日钙摄入量>800mg与所有心血管疾病的风险显着降低相关(比值比[OR],0.27;95%置信区间[CI],0.11-0.64),stroke(OR,0.06;95%CI,0.01-0.42),和心肌梗塞(OR,0.27;95%CI,0.11-0.64)。我们的研究结果表明,膳食钙摄入量>800毫克/天降低了绝经时间>10年的女性发生CVD事件的风险。
We aimed to evaluate the association between daily dietary calcium intake and the risk of cardiovascular disease (CVD) in postmenopausal women using data from the Korean National Health and Nutrition Examination Survey (KNHANES). This cross-sectional study included 12,348 women aged 45-70 years who had reached natural menopause. They were classified into three groups according to daily dietary calcium intake: <400 mg, 400-800 mg, and >800 mg. The risks of CVD, stroke, angina, and myocardial infarction were assessed in each group. Further, we performed subgroup analysis according to the post-menopause duration (≤10 vs. >10 postmenopausal years). We performed logistic regression analysis with adjustment for age, menopausal age, income, urban area, education, insulin use, body mass index, hypertension, diabetes mellitus, dyslipidemia, high alcohol intake, smoking, exercise, oral contraceptive use, and hormonal therapy use. Calcium intake level was not significantly associated with the risk of CVD in the total population and the ≤10 postmenopausal years subgroup. However, in the >10 postmenopausal years subgroup, daily calcium intake >800 mg was associated with significantly decreased risks of all CVD (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.11-0.64), stroke (OR, 0.06; 95% CI, 0.01-0.42), and myocardial infarction (OR, 0.27; 95% CI, 0.11-0.64). Our findings suggest that a dietary calcium intake of >800 mg/day decreases the risk of CVD events in women who have been menopausal for >10 years.