METHODS: A total of 465 adolescents (aged 12-18 years; 255 boys and 210 girls) based on data from the 2014-2015 Korea National Health and Nutrition Examination Survey were included. Serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (fT4) were used to assess thyroid function, whereas the homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), glucose/insulin ratio (GIR), triglyceride-glucose (TyG) index, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to assess IR. The relationship between thyroid function and IR was analyzed using multiple linear regressions stratified by sex, considering obesity status.
RESULTS: The relationship between thyroid function and IR varied depending on sex and was more pronounced in the overweight/obesity subgroup for both boys and girls. In overweight and obese boys and girls, fT4 was significantly associated with HOMA-IR and QUICKI with conflicting association directions. TSH was also positively associated with the TyG index in both sexes.
CONCLUSIONS: The findings suggest that the relationship between thyroid function and IR in adolescents might vary depending on sex, and the degree of association was significant in obese adolescents.
方法:根据2014-2015年韩国国家健康和营养调查的数据,共纳入465名青少年(12-18岁;255名男孩和210名女孩)。血清促甲状腺激素(促甲状腺激素[TSH])和游离甲状腺素(fT4)用于评估甲状腺功能,而胰岛素抵抗的稳态模型评估(HOMA-IR),定量胰岛素敏感性检查指数(QUICKI),葡萄糖/胰岛素比(GIR),甘油三酯-葡萄糖(TyG)指数,用甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值评估IR。采用按性别分层的多元线性回归分析甲状腺功能与IR的关系,考虑肥胖状况。
结果:甲状腺功能与IR之间的关系因性别而异,在男孩和女孩的超重/肥胖亚组中更为明显。在超重和肥胖的男孩和女孩中,fT4与HOMA-IR和QUICKI显著相关,关联方向相互冲突。两种性别的TSH也与TyG指数呈正相关。
结论:研究结果表明,青少年甲状腺功能与IR之间的关系可能因性别而异,肥胖青少年的关联程度显著。