PDF(Pubmed)
Abstract：
OBJECTIVE: This study investigated the sex-specific association between thyroid function and various insulin resistance (IR) indices, including noninsulin-based IR indices, in euthyroid adolescents.
METHODS: A total of 465 adolescents (aged 12-18 years; 255 boys and 210 girls) based on data from the 2014-2015 Korea National Health and Nutrition Examination Survey were included. Serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (fT4) were used to assess thyroid function, whereas the homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), glucose/insulin ratio (GIR), triglyceride-glucose (TyG) index, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to assess IR. The relationship between thyroid function and IR was analyzed using multiple linear regressions stratified by sex, considering obesity status.
RESULTS: The relationship between thyroid function and IR varied depending on sex and was more pronounced in the overweight/obesity subgroup for both boys and girls. In overweight and obese boys and girls, fT4 was significantly associated with HOMA-IR and QUICKI with conflicting association directions. TSH was also positively associated with the TyG index in both sexes.
CONCLUSIONS: The findings suggest that the relationship between thyroid function and IR in adolescents might vary depending on sex, and the degree of association was significant in obese adolescents.
METHODS: A total of 465 adolescents (aged 12-18 years; 255 boys and 210 girls) based on data from the 2014-2015 Korea National Health and Nutrition Examination Survey were included. Serum thyrotropin (thyroid-stimulating hormone [TSH]) and free thyroxine (fT4) were used to assess thyroid function, whereas the homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI), glucose/insulin ratio (GIR), triglyceride-glucose (TyG) index, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio were used to assess IR. The relationship between thyroid function and IR was analyzed using multiple linear regressions stratified by sex, considering obesity status.
RESULTS: The relationship between thyroid function and IR varied depending on sex and was more pronounced in the overweight/obesity subgroup for both boys and girls. In overweight and obese boys and girls, fT4 was significantly associated with HOMA-IR and QUICKI with conflicting association directions. TSH was also positively associated with the TyG index in both sexes.
CONCLUSIONS: The findings suggest that the relationship between thyroid function and IR in adolescents might vary depending on sex, and the degree of association was significant in obese adolescents.
摘要：
目的：本研究调查了甲状腺功能与各种胰岛素抵抗（IR）指数之间的性别特异性关联。包括基于非胰岛素的IR指数，甲状腺功能正常的青少年。
方法：根据2014-2015年韩国国家健康和营养调查的数据，共纳入465名青少年（12-18岁；255名男孩和210名女孩）。血清促甲状腺激素（促甲状腺激素[TSH]）和游离甲状腺素（fT4）用于评估甲状腺功能，而胰岛素抵抗的稳态模型评估(HOMA-IR)，定量胰岛素敏感性检查指数（QUICKI），葡萄糖/胰岛素比（GIR），甘油三酯-葡萄糖（TyG）指数，用甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值评估IR。采用按性别分层的多元线性回归分析甲状腺功能与IR的关系,考虑肥胖状况。
结果：甲状腺功能与IR之间的关系因性别而异，在男孩和女孩的超重/肥胖亚组中更为明显。在超重和肥胖的男孩和女孩中，fT4与HOMA-IR和QUICKI显著相关,关联方向相互冲突。两种性别的TSH也与TyG指数呈正相关。
结论：研究结果表明，青少年甲状腺功能与IR之间的关系可能因性别而异，肥胖青少年的关联程度显著。
方法：根据2014-2015年韩国国家健康和营养调查的数据，共纳入465名青少年（12-18岁；255名男孩和210名女孩）。血清促甲状腺激素（促甲状腺激素[TSH]）和游离甲状腺素（fT4）用于评估甲状腺功能，而胰岛素抵抗的稳态模型评估(HOMA-IR)，定量胰岛素敏感性检查指数（QUICKI），葡萄糖/胰岛素比（GIR），甘油三酯-葡萄糖（TyG）指数，用甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值评估IR。采用按性别分层的多元线性回归分析甲状腺功能与IR的关系,考虑肥胖状况。
结果：甲状腺功能与IR之间的关系因性别而异，在男孩和女孩的超重/肥胖亚组中更为明显。在超重和肥胖的男孩和女孩中，fT4与HOMA-IR和QUICKI显著相关,关联方向相互冲突。两种性别的TSH也与TyG指数呈正相关。
结论：研究结果表明，青少年甲状腺功能与IR之间的关系可能因性别而异，肥胖青少年的关联程度显著。
