■与输血和体内铁超负荷有关的全球最常见的血红蛋白病之一是地中海贫血综合征。增加铁蛋白水平会对患者的身体器官造成严重损害。这项研究旨在评估输血依赖性β-地中海贫血患者重要身体器官铁过载的并发症。
■这项描述性横断面研究是在伊朗医科大学医院对经常输血的β-地中海贫血患者进行的。为了评估铁过载对重要身体器官的影响,血液学和血液分析,超声心动图测量肺动脉压(PAP)和射血分数(EF)测试,骨密度测定,对所有患者进行听力测试。
■在参与这项研究的1010名患者中,497(49%)为男性,513名(51%)5-74岁女性,大多数参与者(85%)超过20岁。这项研究表明,增加铁蛋白水平与性别没有显著相关性,胆固醇,低密度脂蛋白,甲状旁腺激素,T4和天冬氨酸转氨酶。然而,铁蛋白水平升高与甘油三酯升高有显著相关性,磷,促甲状腺激素,碱性磷酸酶,丙氨酸转氨酶,和PAP水平,年龄,听力障碍,脾切除术,骨质疏松,减少高密度脂蛋白,身体质量指数,钙,和EF水平。
■β-地中海贫血患者的生存和生活质量的改善可能是由于通过定期随访和早期并发症检测在综合单位中进行多学科护理。
UNASSIGNED: One of the most common hemoglobinopathies globally related to blood transfusion and iron overload in the body is thalassemia syndrome. Increasing ferritin levels can cause severe damage to the patient\'s body organs. This study aims to evaluate the complications of iron overload on vital body organs in patients with transfusion-dependent beta-thalassemia.
UNASSIGNED: This descriptive cross-sectional study was performed in Iran University of Medical Sciences Hospitals on patients with a beta-thalassemia major with frequent blood transfusions. To evaluate the effect of iron overload on vital body organs, hematologic and blood analysis, echocardiography with measurement of pulmonary artery pressure (PAP) and ejection fraction (EF) tests, bone densitometry, and audiometric tests were performed for all patients.
UNASSIGNED: Of the 1010 patients participating in this study, 497 (49%) were males, 513 were (51%) females aged 5-74 years, and the majority of participants (85%) were over 20 years old. This study demonstrated that increasing ferritin levels had no notable correlation with sex, cholesterol, low-density lipoprotein, parathyroid hormone, T4, and aspartate aminotransferase. However, elevating ferritin levels had significant correlations with increasing triglyceride, phosphorus, thyroid stimulating hormone, alkaline phosphatase, alanine transaminase, and PAP levels, age, hearing disorders, splenectomy, osteoporosis, and decreasing high-density lipoprotein, body mass index, calcium, and EF levels.
UNASSIGNED: Improvement in beta-thalassemia patients\' survival and quality of life can be due to multidisciplinary care in a comprehensive unit through regular follow-up and early complication detection.