UNASSIGNED: This was a cross-sectional study conducted between November 2019 and November 2021 at seven tertiary hospitals in Malaysia. Participants registered with Malaysian Thalassemia Registry were recruited by convenience sampling. Adherence was measured via pill count and self-reported adherence. Knowledge about thalassemia and ICT was measured using a questionnaire from Modul Thalassemia by Ministry of Health of Malaysia. A decision tree was used to identify predictors of non-adherence.
UNASSIGNED: A total of 135 patients were recruited. The prevalence of non-adherence to ICT in those who took subcutaneous ± oral medications was 47.5% (95% CI: 31.5%, 63.9%) and the prevalence of non-adherence to ICT in those who took oral medications only was 21.1% (95% CI: 13.4%, 30.6%). The median knowledge score was 67.5% (IQR 15%). A decision tree has identified two factors associated with non-adherence. They were ICT\'s route of administration and knowledge score. Out of 100 patients who were on oral medications only, 79 were expected to adhere. Out of 100 patients who were on subcutaneous ± oral medications and scored less than 56.25% in knowledge questionnaire, 86 were expected to non-adhere. Based on the logistic regression, the odds of non-adherence in patients who took oral medications only was 71% lower than the odds of non-adherence in patients who took subcutaneous ± oral medications (OR = 0.29; 95% CI = 0.13, 0.65; p = .002).
UNASSIGNED: The prevalence of non-adherence to ICT among children with beta thalassemia major in Malaysia was 20/95 (21.1%) in those who took oral medications only and the prevalence of non-adherence was 19/40 (47.5%) in those who took subcutaneous ± oral medications. The factors associated with non-adherence were ICT\'s route of administration and knowledge score.
■这是2019年11月至2021年11月在马来西亚七家三级医院进行的一项横断面研究。通过便利抽样招募在马来西亚地中海贫血登记处注册的参与者。通过药丸计数和自我报告的依从性来测量依从性。马来西亚卫生部使用来自Modul地中海贫血的问卷测量了有关地中海贫血和ICT的知识。决策树用于识别非依从性的预测因子。
■共招募了135名患者。服用皮下±口服药物的患者不遵守ICT的患病率为47.5%(95%CI:31.5%,63.9%),仅服用口服药物的人不遵守ICT的患病率为21.1%(95%CI:13.4%,30.6%)。中位知识得分为67.5%(IQR15%)。决策树已经确定了与不遵守相关的两个因素。它们是ICT的管理路线和知识得分。在仅接受口服药物治疗的100名患者中,预计将坚持79。在接受皮下±口服药物治疗的100例患者中,知识问卷得分低于56.25%,预计有86人不坚持。基于逻辑回归,仅服用口服药物的患者出现不依从的几率比服用皮下±口服药物的患者出现不依从的几率低71%(OR=0.29;95%CI=0.13,0.65;p=.002).
■在马来西亚,在仅服用口服药物的儿童中,不遵守ICT的患病率为20/95(21.1%),在服用皮下±口服药物的儿童中,不遵守的患病率为19/40(47.5%)。与不依从性相关的因素是ICT的给药途径和知识得分。