METHODS: This study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, \"iron chelators\" and \"viral infection\", was employed.
RESULTS: According to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections via various mechanisms, with natural ICs being the most extensively used.
CONCLUSIONS: Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.
方法:本研究设计为系统综述,其中搜索策略集中在两个电子数据库上,PubMed,还有Scopus,2017年至2021年。有两个主题的搜索过滤器,“铁螯合剂”和“病毒感染”,被雇用。
结果:根据结果,天然和合成螯合剂通过各种机制对病毒感染的治疗产生了相当大的影响,天然IC是最广泛使用的。
结论:天然和合成ICs通过不同的药理机制发挥作用。在这些化合物中,天然螯合剂由于其安全性而被更广泛地使用,功效,和更广泛的应用。