Abstract：
BACKGROUND: Iron chelators (ICs) have recently emerged as one of the new methods of treatment for viral infections. This study aimed to evaluate the efficiency and safety of natural ICs compared to synthetic ICs. Natural and synthetic ICs are the most common therapeutic agents tested for the treatment of viral infections. When evaluated against synthetic ICs, natural ICs are probably favored owing to their lower toxicity and safer properties. The main objective of the present systematic review was to assess the current evidence on the role of pharmacological mechanisms in the treatment of viral infections.
METHODS: This study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, \"iron chelators\" and \"viral infection\", was employed.
RESULTS: According to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections via various mechanisms, with natural ICs being the most extensively used.
CONCLUSIONS: Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.
METHODS: This study was designed as a systematic review in which search strategies were focused on two electronic databases, PubMed, and Scopus, between 2017 and 2021. A search filter with two subjects, \"iron chelators\" and \"viral infection\", was employed.
RESULTS: According to the results, both natural and synthetic chelators had a considerable impact on the treatment of viral infections via various mechanisms, with natural ICs being the most extensively used.
CONCLUSIONS: Natural and synthetic ICs exert their effects through different pharmacological mechanisms. Among these compounds, natural chelators are more widely used due to their safety, efficacy, and a wider range of applications.
摘要：
背景：铁螯合剂（IC）最近已成为治疗病毒感染的新方法之一。本研究旨在评估与合成IC相比，天然IC的效率和安全性。天然和合成IC是被测试用于治疗病毒感染的最常见的治疗剂。当针对合成IC进行评估时，天然ICs可能因其低毒性和更安全的特性而受到青睐。本系统综述的主要目的是评估当前关于药理学机制在病毒感染治疗中的作用的证据。
方法：本研究设计为系统综述，其中搜索策略集中在两个电子数据库上，PubMed,还有Scopus,2017年至2021年。有两个主题的搜索过滤器，“铁螯合剂”和“病毒感染”，被雇用。
结果：根据结果，天然和合成螯合剂通过各种机制对病毒感染的治疗产生了相当大的影响，天然IC是最广泛使用的。
结论：天然和合成ICs通过不同的药理机制发挥作用。在这些化合物中,天然螯合剂由于其安全性而被更广泛地使用，功效,和更广泛的应用。
方法：本研究设计为系统综述，其中搜索策略集中在两个电子数据库上，PubMed,还有Scopus,2017年至2021年。有两个主题的搜索过滤器，“铁螯合剂”和“病毒感染”，被雇用。
结果：根据结果，天然和合成螯合剂通过各种机制对病毒感染的治疗产生了相当大的影响，天然IC是最广泛使用的。
结论：天然和合成ICs通过不同的药理机制发挥作用。在这些化合物中,天然螯合剂由于其安全性而被更广泛地使用，功效,和更广泛的应用。
