■中性粒细胞与高密度脂蛋白胆固醇比率(NHR),单核细胞与高密度脂蛋白胆固醇比率(MHR),淋巴细胞与高密度脂蛋白胆固醇比率(LHR),血小板与高密度脂蛋白胆固醇比值(PHR),全身免疫炎症指数(SII),全身炎症反应指数(SIRI),全身炎症综合指数(AISI)已被确定为与心血管疾病预后相关的免疫炎症生物标志物。然而,这些生物标志物与非阻塞性冠状动脉心肌梗死(MINOCA)预后的关系尚不清楚.
■在联合后勤支援部队第920医院行冠状动脉造影的MINOCA患者纳入本研究。从医院记录系统收集临床基线特征和实验室测试数据。根据主要不良心血管事件(MACE)的发生情况分为两组。进行多元logistic回归分析以评估NHR,MHR,LHR,PHR,SII,SIRI,AISI,和MACE。产生受试者工作特征(ROC)曲线以评估NHR的预测值,MHR,LHR,PHR,SII,SIRI,和AISI用于MINOCA患者的MACE。预测的准确性由曲线下面积(AUC)值表示。
■该研究包括335名MINOCA患者。(MACE组中的81和No-MACE组中的254)。MACE组的NHR水平较高,MHR,LHR,PHR,SII,SIRI,和AISI比No-MACE组。校正混杂因素的多元逻辑回归分析表明,NHR水平越高,MHR,PHR,SII,SIRI,和AISI与MINOCA患者MACE的发生有关(P<0.001)。NHR的AUC值,MHR,PHR,SII,SIRI,AISI分别为0.695、0.747、0.674、0.673、0.688和0.676。NHR的组合,MHR,PHR,SII,SIRI,和AISI提高了预测MINOCA患者MACE的准确性(AUC=0.804)。
■较高水平的NHR,MHR,PHR,SII,SIRI,AISI与MACE的发生有关,和NHR的组合,MHR,PHR,SII,SIRI,AISI提高了预测MINOCA患者MACE事件发生率的准确性.
UNASSIGNED: Neutrophil-to-high-density lipoprotein cholesterol ratio (NHR), monocyte-to-high-density lipoprotein cholesterol ratio (MHR), lymphocyte-to-high-density lipoprotein cholesterol ratio (LHR), platelet-to-high-density lipoprotein cholesterol ratio (PHR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) have been identified as immune-inflammatory biomarkers associated with the prognosis of cardiovascular diseases. However, the relationship of these biomarkers with the prognosis of myocardial infarction with non-obstructive coronary arteries (MINOCA) remains unclear.
UNASSIGNED: Patients with MINOCA who underwent coronary angiography at the 920th Hospital of Joint Logistics Support Force were included in our study. Clinical baseline characteristics and laboratory testing data were collected from the hospital record system. The patients were divided into two groups on the basis of major adverse cardiovascular events (MACE) occurrence. Multiple logistic regression analysis was conducted to assess the relationship between NHR, MHR, LHR, PHR, SII, SIRI, AISI, and MACE. Receiver operating characteristic (ROC) curves were generated to evaluate the predictive value of NHR, MHR, LHR, PHR, SII, SIRI, and AISI for MACE in patients with MINOCA. The accuracy of the prediction was indicated by the area under the curve (AUC) value.
UNASSIGNED: The study included 335 patients with MINOCA. (81 in the MACE group and 254 in the No-MACE group). The MACE group had higher levels of NHR, MHR, LHR, PHR, SII, SIRI, and AISI than the No-MACE group. Multiple logistic regression analysis adjusted for confounding factors indicated that the higher levels of NHR, MHR, PHR, SII, SIRI, and AISI were associated with the occurrence of MACE in patients with MINOCA (P < 0.001). The AUC values for NHR, MHR, PHR, SII, SIRI, and AISI were 0.695, 0.747, 0.674, 0.673, 0.688, and 0.676, respectively. The combination of NHR, MHR, PHR, SII, SIRI, and AISI improved the accuracy of predicting MACE in patients with MINOCA (AUC = 0.804).
UNASSIGNED: Higher levels of NHR, MHR, PHR, SII, SIRI, and AISI were associated with the occurrence of MACE, and the combination of NHR, MHR, PHR, SII, SIRI, and AISI improved the accuracy for predicting the incidence of MACE events in patients with MINOCA.