Rosa roxburghii Tratt juice inhibits NF-κB and increases IL-2 to alleviates the Foxp3-mediated Tregs imbalance in the peripheral blood of arseniasis patients.

刺梨汁抑制 NF - κ B 并增加 IL - 2 ， 以减轻砷中毒患者外周血中 Foxp3 介导的 Tregs 失衡。

• 影响指数: 3.231
• 发表时间: 2024 Mar
• 来源期刊: Food Sci Biotechnol
• DOI: 10.1007/s10068-023-01384-0
• PMID: 38371687
• 文章类型: Journal Article
• 作者列表: Wang Q,Fang X,Sun B,Zhu K,Yao M,Wei S,Zhang A

关键词: Arsenic; IL-2; Immune inflammation; NF-κB; Rosa roxburghii Tratt; Tregs imbalance

Abstract

Arsenic can cause immune inflammation, which is the basis of arsenic-induced damage to multiple organs and systems. Forkhead box P3 (Foxp3)-labelled CD4+CD25+ regulatory T cells (Tregs) play an essential role in maintaining immune homeostasis. Nuclear factor-κb (NF-κB) and Interleukin-2 (IL-2) are critical regulators of Foxp3. Rosa roxburghii Tratt (RRT) is an edible medicinal plant with anti-inflammation effects. In this study, a control group (n = 41) and an arseniasis group (n = 209) were recruited, and screened subjects from the arseniasis patients for RRTJ (n = 46) or placebo (n = 43) to explore the possible mechanism by which RRT alleviates immune inflammation. The results indicated that RRTJ can inhibits NF-κB and increases IL-2, and alleviates the Foxp3-mediated Tregs imbalance in the peripheral blood of arseniasis patients. In summary, these findings suggest a novel intervention or therapeutic target for immune inflammation in arseniasis patients and provide new evidence that RRTJ inhibits immune inflammation.
UNASSIGNED:
UNASSIGNED: The online version contains supplementary material available at 10.1007/s10068-023-01384-0.

摘要

砷可以引起免疫炎症，这是砷对多个器官和系统造成损害的基础。叉头盒P3(Foxp3)标记的CD4+CD25+调节性T细胞(Tregs)在维持免疫稳态中起重要作用。核因子-κB(NF-κB)和白细胞介素-2(IL-2)是Foxp3的关键调节因子。刺梨（RRT）是一种具有抗炎作用的可食用药用植物。在这项研究中,对照组（n=41）和砷中毒组（n=209）被招募，并从砷中毒患者中筛选RRTJ（n=46）或安慰剂（n=43）的受试者，以探讨RRT减轻免疫炎症的可能机制。结果表明,RRTJ能抑制NF-κB,增加IL-2,减轻Foxp3介导的砷中毒患者外周血Tregs失衡。总之,这些发现提示了砷中毒患者免疫炎症的新干预或治疗靶点,并为RRTJ抑制免疫炎症提供了新的证据.
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■在线版本包含补充材料，可在10.1007/s10068-023-01384-0获得。