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Abstract：
Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl-, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets.
摘要：
溶酶体是高度动态的细胞器，可通过整合多种代谢途径来维持细胞稳态并调节基本的细胞过程。溶酶体离子通道如TRPML1-3、TPC1/2、ClC6/7、CLN7和TMEM175介导Ca2+的流动，Cl-,Na+,H+,和K+穿过溶酶体膜以响应渗透刺激，营养依赖性信号，和细胞压力。这些离子通道作为细胞信号的关键传感器，对于溶酶体生物发生的调节是必不可少的，运动性,膜接触位点的形成，和溶酶体稳态。在病理生理学方面，这些通道基因的遗传变异与溶酶体贮积病的发展有关，神经退行性疾病，炎症,和癌症。这篇综述旨在讨论目前对这些离子通道在中枢神经系统中的作用的理解，并评估它们作为药物靶标的潜力。
