本手稿旨在回顾自首次描述以来有关林奇综合症的历史发展和最重要的贡献,一个多世纪前。1895年,密歇根大学著名病理学家,AldredScottWarthin博士,对当地一位名叫PaulineGross的女裁缝的家族史很感兴趣.根据她的预测,她会因为癌症而提前死亡,这实际上是(从子宫)发生的。历史上,她的家人被指定为“家庭G”,包括一组被认为是有史以来研究过的最长和最详细的癌症谱系。Warthin得出结论,其成员对癌症有遗传易感性,他们是,如今,被认为是第一个报道的林奇综合症家族。当时,然而,癌症医学界对遗传和癌症之间的联系的接受度要低得多,尽管其他家族的描述有类似的遗传图谱。不幸的是,这一历史事实一直处于休眠状态,直到另一位研究者开启了对家族癌症集群的理解的新时代。在这个家庭和许多其他人的报告和研究之后,最初被称为癌症家庭综合症的疾病被改为原名林奇综合症。这是对亨利·林奇博士在描述这种疾病的各种特征方面所开展的广泛而专注的工作的认可,以及他为其诊断和治疗建立正确建议的努力。尽管未来宣布对林奇综合症的全面了解还有很长的路要走,波琳直觉的杰出贡献,Warthin的毅力,和林奇的工作一致性绝不能被那些已经或将受益于这些知识的人遗忘。
The present manuscript aimed to review the historical development and most important contributions regarding Lynch Syndrome since its first description, more than a century ago. In 1895, a reputed pathologist from Michigan University, Dr. Aldred Scott Warthin, got intrigued by the family history of a local seamstress called Pauline Gross. According to her prevision, she would present an early death due to cancer, which actually happened (from the uterus). Historically, her family was designated \"Family G\", comprising a group recognized as the longest and most detailed cancer genealogy that has ever been studied. Warthin concluded that its members had genetic susceptibility for cancer, and they are, nowadays, considered the first reported Lynch Syndrome family. At that time, however, the medical cancer community was far less receptive to the association between heredity and cancer, despite the description of other families with similar heredograms. Unfortunately, this historical fact remained somewhat dormant until another investigator inaugurated a new era in the understanding of family cancer clusters. After reports and studies from this family and many others, the condition initially called Cancer Family Syndrome was changed to the eponym Lynch Syndrome. This was a recognition of the extensive and dedicated work developed by Dr. Henry Lynch in describing various characteristics of the disease, and his efforts to establish the correct recommendations for its diagnosis and treatment. Although the future announces there is still far to go for a complete understanding of Lynch Syndrome, the remarkable contributions of Pauline\'s intuition, Warthin\'s perseverance, and Lynch\'s work consistency must never be forgotten by those who already have or will still benefit from this knowledge.