Abstract：
The bromodomain and extra-terminal (BET) family of proteins reads epigenetic histone acetylation marks on the genome and regulates the transcriptional machinery. In their study, Carole LaBonne and colleagues reveal the role of BET protein activity in the maintenance of pluripotency and establishment of the neural crest in Xenopus laevis. To know more about their work, we spoke to the first author Paul Huber and the corresponding author Carole LaBonne, Developmental and Stem Cell Biologist at Northwestern University.
摘要：
蛋白质的溴结构域和末端外（BET）家族读取基因组上的表观遗传组蛋白乙酰化标记并调节转录机制。在他们的研究中,CaroleLaBonne及其同事揭示了BET蛋白活性在非洲爪狼多能性维持和神经c建立中的作用。想更多地了解他们的工作，我们采访了第一作者PaulHuber和通讯作者CaroleLaBonne,西北大学发育和干细胞生物学家。
