■高体重指数(BMI)可能表明超重或肥胖,并且是乳腺癌幸存者的关键风险因素。然而,高BMI与早期乳腺癌(EBC)预后之间的关系尚不清楚.我们旨在评估高BMI对EBC患者预后的影响。
■PubMed,Embase,我们检索了截至2021年11月与BMI对乳腺癌预后影响相关的Cochrane图书馆数据库和主要肿瘤会议记录.使用固定和随机效应模型进行荟萃分析。从纳入的文献中提取无病生存期(DFS)和总生存期(OS)的合并风险比(HR)和95%置信区间(CI)。
■包括33,836例EBC患者的20项回顾性队列研究。超重患者的DFS(HR:1.16,95%CI:1.05-1.27,P=0.002)和OS(HR:1.20;95%CI:1.09-1.33,P<0.001)较差。肥胖对DFS(HR:1.17,95%CI:1.07~1.29,P=0.001)和OS(HR:1.30,95%CI:1.17~1.45,P<0.001)也有不良影响。同样,高BMI患者的DFS(HR:1.16,95%CI:1.08~1.26,P<0.001)和OS(HR:1.25,95%CI:1.14~1.39,P<0.001)较差。在亚组分析中,在多变量分析中,超重对DFS(HR:1.11,95%CI:1.04-1.18,P=0.001)和OS(HR:1.18,95%CI:1.11-1.26,P<0.001)有不利影响,而超重对DFS(HR:1.21,95%CI:0.99-1.48,P=0.058)和OS(HR:1.39,95%CI:0.92-2.10,P=0.123)的影响无统计学意义。相比之下,肥胖对DFS(HR:1.21,95%CI:1.06-1.38,P=0.004和HR:1.14,95%CI:1.08-1.22,P<0.001)和OS(HR:1.33,95%CI:1.15-1.54,P<0.001和HR:1.23,95%CI:1.15-1.31,P<0.001)有不利影响。分别。
■与正常体重相比,体重增加(超重,肥胖,高BMI)导致EBC患者DFS和OS恶化。一旦验证,在制定预防计划时应考虑这些结果。
UNASSIGNED: A high body mass index (BMI) can indicate overweight or obesity and is a crucial risk factor for breast cancer survivors. However, the association between high BMI and prognosis in early-stage breast cancer (EBC) remains unclear. We aimed to assess the effects of high BMI on the prognosis of patients with EBC.
UNASSIGNED: The PubMed, Embase, and Cochrane Library databases and proceedings of major oncological conferences related to the effects of BMI on the prognosis of breast cancer were searched up to November 2021. Fixed- and random-effects models were used for meta-analyses. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for disease-free survival (DFS) and overall survival (OS) were extracted from the included literature.
UNASSIGNED: Twenty retrospective cohort studies with 33,836 patients with EBC were included. Overweight patients had worse DFS (HR: 1.16, 95% CI: 1.05-1.27, P = 0.002) and OS (HR: 1.20; 95% CI: 1.09-1.33, P < 0.001). Obesity also had adverse effects on DFS (HR: 1.17, 95% CI: 1.07-1.29, P = 0.001) and OS (HR: 1.30, 95% CI: 1.17-1.45, P < 0.001). Likewise, patients with high BMI had worse DFS (HR: 1.16, 95% CI: 1.08-1.26, P < 0.001) and OS (HR: 1.25, 95% CI: 1.14-1.39, P < 0.001). In subgroup analyses, overweight had adverse effects on DFS (HR: 1.11, 95% CI: 1.04-1.18, P = 0.001) and OS (HR: 1.18, 95% CI: 1.11-1.26, P < 0.001) in multivariate analyses, whereas the relationship that overweight had negative effects on DFS (HR: 1.21, 95% CI: 0.99-1.48, P = 0.058) and OS (HR: 1.39, 95% CI: 0.92-2.10, P = 0.123) was not statistically significant in univariate analysis. By contrast, obesity had adverse effects on DFS (HR: 1.21, 95% CI: 1.06-1.38, P = 0.004 and HR: 1.14, 95% CI: 1.08-1.22, P < 0.001) and OS (HR: 1.33, 95% CI: 1.15-1.54, P < 0.001 and HR: 1.23, 95% CI: 1.15-1.31, P < 0.001) in univariate and multivariate analyses, respectively.
UNASSIGNED: Compared with normal weight, increased body weight (overweight, obesity, and high BMI) led to worse DFS and OS in patients with EBC. Once validated, these results should be considered in the development of prevention programs.