PDF(Pubmed)
Abstract：
UNASSIGNED: With the prevalence of high body mass index (HBMI) increasing over the past 30 years, it is essential to examine the impact of obesity on kidney cancer. This study aims to explore the attributable burden of kidney cancer associated with HBMI and its proportion at different levels.
UNASSIGNED: The data used in this research were obtained from the Global Burden of Diseases Study 2019. We utilized DisMod-MR 2.1, a Bayesian meta-regression tool, to estimate the burden of kidney cancer attributable to HBMI, which was measured by age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years rate (ASDR). Correlation analysis was conducted by the Spearman rank order correlation method. The temporal trends were analyzed by estimating the estimated annual percentage change (EAPC).
UNASSIGNED: Globally in 2019, there were a total of 31.7 thousand deaths and 751.89 thousand disability-adjusted life years (DALYs) attributable to kidney cancer caused by HBMI, increased by 183.1 and 164%, respectively. Over the period from 1990 to 2019, the burden of kidney cancer attributable to HBMI increased in all regions, with the most significant increases occurring in Low-middle socio-demographic index (SDI) and Low SDI regions. At the national level, countries with lower SDI had lower ASMR and ASDR compared to developed nations. However, the EAPC values, which indicate the rate of increase, were significantly higher in these countries than in developed nations. Furthermore, across all years from 1990 to 2019, males experienced a greater and more rapidly increasing burden of kidney cancer attributable to HBMI than females.
UNASSIGNED: As the population grows and dietary patterns shift, the burden of kidney cancer attributable to HBMI is expected to become even more severe. Males and developed regions have borne a heavier burden from 1990 to 2019. However, the EAPC values for both ASMR and ASDR were higher in males but not in regions with higher SDI values.
UNASSIGNED: The data used in this research were obtained from the Global Burden of Diseases Study 2019. We utilized DisMod-MR 2.1, a Bayesian meta-regression tool, to estimate the burden of kidney cancer attributable to HBMI, which was measured by age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years rate (ASDR). Correlation analysis was conducted by the Spearman rank order correlation method. The temporal trends were analyzed by estimating the estimated annual percentage change (EAPC).
UNASSIGNED: Globally in 2019, there were a total of 31.7 thousand deaths and 751.89 thousand disability-adjusted life years (DALYs) attributable to kidney cancer caused by HBMI, increased by 183.1 and 164%, respectively. Over the period from 1990 to 2019, the burden of kidney cancer attributable to HBMI increased in all regions, with the most significant increases occurring in Low-middle socio-demographic index (SDI) and Low SDI regions. At the national level, countries with lower SDI had lower ASMR and ASDR compared to developed nations. However, the EAPC values, which indicate the rate of increase, were significantly higher in these countries than in developed nations. Furthermore, across all years from 1990 to 2019, males experienced a greater and more rapidly increasing burden of kidney cancer attributable to HBMI than females.
UNASSIGNED: As the population grows and dietary patterns shift, the burden of kidney cancer attributable to HBMI is expected to become even more severe. Males and developed regions have borne a heavier burden from 1990 to 2019. However, the EAPC values for both ASMR and ASDR were higher in males but not in regions with higher SDI values.
摘要：
■在过去30年中，随着高体重指数（HBMI）的患病率增加，检查肥胖对肾癌的影响至关重要。本研究旨在探讨与HBMI相关的肾癌归因负担及其在不同水平上的比例。
■本研究中使用的数据来自2019年全球疾病负担研究。我们使用了DisMod-MR2.1，一个贝叶斯元回归工具，为了估计归因于HBMI的肾癌负担，通过年龄标准化死亡率(ASMR)和年龄标准化残疾校正寿命年率(ASDR)衡量.采用Spearman秩序相关方法进行相关分析。通过估计年度百分比变化(EAPC)来分析时间趋势。
■在2019年全球范围内，HBMI引起的肾癌导致的死亡总数为31.7万人，残疾调整生命年（DALYs）为751.89万人，增加了183.1和164%，分别。在1990年至2019年期间，HBMI引起的肾癌负担在所有地区都有所增加，最显著的增长发生在中低社会人口指数(SDI)和低SDI地区。在国家一级,与发达国家相比，SDI较低的国家ASMR和ASDR较低。然而,EAPC值，这表明了增长率，在这些国家明显高于发达国家。此外，在1990年至2019年的所有年份中，男性比女性经历了由HBMI引起的肾癌负担更大，更迅速地增加。
■随着人口的增长和饮食模式的转变，预计HBMI导致的肾癌负担将变得更加严重.从1990年到2019年，男性和发达地区负担更重。然而,ASMR和ASDR的EAPC值在男性中均较高,但在SDI值较高的地区则不高.
■本研究中使用的数据来自2019年全球疾病负担研究。我们使用了DisMod-MR2.1，一个贝叶斯元回归工具，为了估计归因于HBMI的肾癌负担，通过年龄标准化死亡率(ASMR)和年龄标准化残疾校正寿命年率(ASDR)衡量.采用Spearman秩序相关方法进行相关分析。通过估计年度百分比变化(EAPC)来分析时间趋势。
■在2019年全球范围内，HBMI引起的肾癌导致的死亡总数为31.7万人，残疾调整生命年（DALYs）为751.89万人，增加了183.1和164%，分别。在1990年至2019年期间，HBMI引起的肾癌负担在所有地区都有所增加，最显著的增长发生在中低社会人口指数(SDI)和低SDI地区。在国家一级,与发达国家相比，SDI较低的国家ASMR和ASDR较低。然而,EAPC值，这表明了增长率，在这些国家明显高于发达国家。此外，在1990年至2019年的所有年份中，男性比女性经历了由HBMI引起的肾癌负担更大，更迅速地增加。
■随着人口的增长和饮食模式的转变，预计HBMI导致的肾癌负担将变得更加严重.从1990年到2019年，男性和发达地区负担更重。然而,ASMR和ASDR的EAPC值在男性中均较高,但在SDI值较高的地区则不高.
