Health surveillance

健康监测
  • 文章类型: Journal Article
    全球,缺乏系统收集的有关被监禁者的健康数据。我们在本文中的目的是描述一个项目的形成工作的过程模型,该项目旨在加强对加拿大监狱当局监禁的人的健康监测。我们开发了项目结构和流程,我们正在评估项目合作伙伴关系。通知监狱健康监测重点,我们正在审查有关最佳实践的文献,定性研究,以了解利益相关者的需求和优先事项,和绘图工作,以了解可用的监狱健康相关数据。制定和实施监狱健康监护是循序渐进的,需要时间来建立关系并获得批准。应优先考虑知识使用者的需求和利益,但是,由于可行性以及各种利益相关者的不同需求和目标,实现连贯的愿景可能会面临挑战。发展合作关系可以帮助弥合这一差距。
    Worldwide, there is a lack of systematically collected health data on people who are incarcerated. Our objective in this paper was to describe a process model of formative work for a project to strengthen health surveillance for people incarcerated under a Canadian prison authority. We have developed project structures and processes, and we are evaluating project partnerships. To inform prison health surveillance foci, we are conducting a review of literature on best practices, a qualitative study to understand stakeholders\' needs and priorities, and mapping work to understand available prison health-related data. Developing and implementing prison health surveillance is gradual and developmental, necessitating time to build relationships and obtain approvals. The needs and interests of knowledge users should be prioritized, but there may be challenges to achieving a coherent vision due to feasibility and differing needs and objectives of various stakeholders. Developing collaborative relationships could help bridge this gap.
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  • 文章类型: Journal Article
    背景:人际暴力是一种可以在不同的人和条件下发生的现象。然而,智障人士更容易受到这个问题的影响,对他们的健康和福祉有潜在风险。这项研究的目的是确定作为人际暴力受害者的残疾人的社会人口统计学特征,肇事者的概况和受害者得到照顾后采取的措施。
    方法:这是一个探索性的,描述性,描述性使用进入巴西卫生部的应报告疾病信息系统的人际暴力通知表进行横断面研究。之所以选择圣保罗市,是因为它是拉丁美洲最大的城市,并且拥有比其他城市更快的数据处理系统。该期间涵盖2016年至2022年之间的通知。该信息是在2023年10月至11月之间收集的,并进行了单变量统计分析。使用费希尔的精确检验,显著性水平为5%(α=0.05)。
    结果:在此期间,共有4,603份针对智障人士的通知。身体暴力的形式,忽视/遗弃和心理/道德暴力在15-19岁年龄组更为频繁,而性暴力在10-14岁年龄组更频繁(p<0.001)。在所调查的所有形式中,最常攻击的性别是女性(p<0.001),受害最深的人的肤色是黑色和/或棕色,除了忽视/放弃的情况(p=0.058)。大多数受害者接受的教育很少(p=0.012)。侵略是由一个人犯下的(p<0.001),已知或与受害者有关,如母亲或父亲,除了性暴力案件,其中陌生人是主要肇事者(p<0.001)。肇事者的性别是男性,除了忽视和/或放弃的情况(p<0.001),年龄在25至29岁之间(p=0.004)。在性暴力案件中,强奸是最常见的,所进行的程序是采血,然后预防性传播感染(STIs)是卫生专业人员进行的主要程序(p=0.004)。在接受护理后,大多数转介给健康和社会援助网络,很少向人权参考中心等机构推荐,监护委员会和警察局(p<0.001)。
    结论:智障人士极易受到所研究的暴力形式的影响,尤其是儿童和青少年,黑色或棕色,教育水平低。肇事者通常是亲密的人,男性,比受害者年长。卫生专业人员的转诊没有优先考虑受害者的安全和人权保障。应实施对暴力受害者健康的照顾,考虑到特殊方面,比如智障人士,寻求帮助可能很困难。
    BACKGROUND: Interpersonal violence is a phenomenon that can occur with different people and conditions. However, people with intellectual disabilities have increased vulnerability to this problem, with potential risks to their health and well-being. The aim of this study was to identify the sociodemographic characteristics of people with disabilities who have been victims of interpersonal violence, the profile of the perpetrators and the measures taken after the victims have been cared for.
    METHODS: This is an exploratory, descriptive, cross-sectional study using the Interpersonal Violence Notification Forms entered into the Brazilian Ministry of Health\'s Notifiable Diseases Information System. The city of São Paulo was chosen as the setting because it is the largest city in Latin America and has a faster data processing system than other cities. The period covered notifications made between 2016 and 2022. The information was collected between October and November 2023 and a univariate statistical analysis was carried out. Fisher\'s exact test was used, with a significance level of 5% (α = 0.05).
    RESULTS: There were 4,603 notifications against people with intellectual disabilities in the period. The forms of physical violence, neglect/abandonment and psychological/moral violence were more frequent in the 15-19 age group, while sexual violence was more frequent in the 10-14 age group (p < 0.001). The sex most often attacked was female in all the forms investigated (p < 0.001) and the skin colors of the most victimized people were black and/or brown, except in cases of neglect/abandonment (p = 0.058). Most of the victims had little schooling (p = 0.012). The aggressions were committed by one person (p < 0.001), known or related to the victim, such as mother or father, except in cases of sexual violence, where strangers were the main perpetrators (p < 0.001). The sex of the perpetrator was male, except in cases of neglect and/or abandonment (p < 0.001), and the age was between 25 and 29 (p = 0.004). In cases of sexual violence, rape was the most frequent and the procedures carried out were blood collection followed by prophylaxis for Sexually Transmitted Infections (STIs) were the main procedures carried out by health professionals (p = 0.004). The majority of referrals made after receiving care were to the health and social assistance network, with few referrals to bodies such as the human rights reference center, guardianship council and police stations (p < 0.001).
    CONCLUSIONS: People with intellectual disabilities are highly vulnerable to the forms of violence studied, especially children and adolescents, black or brown, with low levels of education. The perpetrators are usually close people, male and older than the victims. The referrals made by health professionals did not prioritize the victim\'s safety and the guarantee of human rights. Lines of care for the health of victims of violence should be implemented, taking into account special aspects, such as people with intellectual disabilities, whose search for help can be difficult.
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  • 文章类型: Journal Article
    在工作场所接触有害物质会导致人员受伤和死亡。这项研究旨在调查向荷兰毒物信息中心报告的职业暴露的特征和趋势,并调查COVID-19大流行是否对趋势产生影响。
    对2016年1月1日至2022年12月31日期间向荷兰毒物信息中心报告的所有急性职业暴露进行了回顾性分析。有关患者和暴露特征的数据,分析症状及治疗建议。
    在2016年至2022年之间,荷兰毒物信息中心收到了5,508个有关急性职业暴露的电话。在研究的这些年中,关于急性职业暴露的年度电话数量几乎翻了一番(从2016年的475个增加到2022年的936个)。在COVID-19大流行期间和之后(2020年3月至2022年12月),电话数量稳定了,但上升趋势并未受到明显影响。估计每月每1000个人类接触电话中有0.20个电话(95%置信区间:-0.14;0.53)。受害者经常通过多种途径暴露,吸入是最常见的途径(44%),其次是眼部(32%)和皮肤接触(30%)。经常涉及酸(1,138次暴露)和碱(912次暴露)。荷兰毒物信息中心掌握了6,334名病人的资料,尽管暴露的患者总数未知,因为一些受害者没有寻求医疗援助,或由未咨询我们中心的医疗保健专业人员治疗。在接触的时候,13%(n=795)的患者报告没有症状,76%(n=4,805)报告轻度至中度症状,3%(n=183)报告潜在严重症状。9%(n=551)的患者缺少症状信息。建议5%(n=325)的患者接受医院观察和治疗。
    这项研究强调了中毒预防策略的必要性,以减少涉及有害物质的与工作有关的事件的数量。
    涉及有害物质的工作场所事故数量的持续增加令人担忧。应采取全面和多学科的方法,以充分了解危险物质的职业暴露情况,并确定危险因素。
    UNASSIGNED: Exposure to hazardous substances in the workplace can result in injuries and fatalities. This study aimed to investigate the characteristics and trend of occupational exposures reported to the Dutch Poisons Information Centre and to investigate whether the COVID-19 pandemic had an impact on the trend.
    UNASSIGNED: A retrospective analysis of all acute occupational exposures reported to the Dutch Poisons Information Centre between 1 January 2016 and 31 December 2022 was performed. Data on patient and exposure characteristics, symptoms and treatment recommendations were analyzed.
    UNASSIGNED: Between 2016 and 2022, the Dutch Poisons Information Centre received 5,508 calls regarding acute occupational exposures. The annual number of calls on acute occupational exposures almost doubled over the years studied (from 475 in 2016 to 936 in 2022). During and after the COVID-19 pandemic (March 2020-December 2022), the number of calls stabilized, but the upward trend was not significantly affected. There were an estimated 0.20 calls per 1,000 human exposure calls per month (95 per cent confidence interval: -0.14; 0.53). Victims were often exposed through multiple routes, with inhalation being the most common route (44 per cent), followed by ocular (32 per cent) and dermal contact (30 per cent). Acids (1,138 exposures) and alkalis (912 exposures) were often involved. The Dutch Poisons Information Centre had information on 6,334 patients, although the total number of exposed patients was not known as some victims did not seek medical assistance, or were treated by healthcare professionals who did not consult our Centre. At the time of contact, 13 per cent (n = 795) of the patients reported no symptoms, 76 per cent (n = 4,805) reported mild to moderate symptoms and 3 per cent (n = 183) reported potentially severe symptoms. Information on symptoms was missing for 9 per cent (n = 551) of the patients. Hospital observation and treatment were recommended for 5 per cent (n = 325) of the patients.
    UNASSIGNED: This study highlights the necessity for poisoning prevention strategies to reduce the number of work-related incidents involving hazardous substances.
    UNASSIGNED: The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous substances and to identify risk factors.
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  • 文章类型: Journal Article
    在1992年石棉禁令之后,意大利法律规定需要对接触石棉的前工人进行健康监测。
    我们描述了对接触石棉的前工人进行健康监测的结果,进行了27年,1994年至2020年,在巴里大学医院职业医学操作部门。
    我们采用了健康监测协议,这在2018年在国家一级得到了验证。
    共检查了1,405名接触石棉的前工人。我们继续诊断339例的病理(24%的队列接受监测),诊断出一些涉及多种病理的病例。具体来说,在339例中,胸膜斑块被诊断为49.2%,石棉沉滞症占35.9%,恶性胸膜间皮瘤(MPM)占20.3%,睾丸阴道外膜间皮瘤(MTVT)占9.1%,肺癌占5.8%,喉癌占0.8%。
    尽管1992年石棉禁令,与石棉有关的疾病仍然是一个严重的公共卫生问题。重要的是要建立标准,以确保对以前接触过的工人进行健康监测,以最大程度地降低成本。减少侵入性检查的数量,并优化可实现的结果。
    UNASSIGNED: The need for health surveillance of former workers exposed to asbestos was provided by law in Italy after the asbestos ban in 1992.
    UNASSIGNED: We describe the results of the health surveillance of former workers exposed to asbestos, conducted over 27 years, from 1994 to 2020, at the Operative Unit of Occupational Medicine of the University Hospital of Bari.
    UNASSIGNED: We adopted the health surveillance protocol, which was validated at the national level in 2018.
    UNASSIGNED: A total of 1,405 former workers exposed to asbestos were examined. We proceeded with diagnosing pathologies in 339 cases (24% of the cohort subjected to surveillance), with diagnoses of some cases involving multiple pathologies. Specifically, pleural plaques were diagnosed in 49.2% of the 339 cases, asbestosis in 35.9%, malignant pleural mesothelioma (MPM) in 20.3%, mesothelioma of the vaginal tunic of the testis (MTVT) in 9.1%, lung cancer in 5.8%, and laryngeal cancer in 0.8%.
    UNASSIGNED: Despite the 1992 asbestos ban, asbestos-related diseases remain a serious public health issue. It is important to establish criteria that ensure the health surveillance of formerly exposed workers minimizes costs, reduces the number of invasive examinations, and optimizes achievable results.
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  • 文章类型: Journal Article
    小反刍动物的驱虫抗性是一个严重的世界性问题。为了减少它们的传播,了解农场蠕虫的流行情况和采取的控制措施至关重要。由于意大利南部卡拉布里亚地区的这些研究是零碎和过时的,对该地区小型反刍动物中蠕虫的患病率进行了研究。还通过对农民的问卷调查评估了控制蠕虫的措施。特别是,在90个农场(45只绵羊和45只山羊),春季收集了900只绵羊和900只山羊的1800份粪便样本。使用FLOTAC双重技术,寄生虫学检查表明,100%的绵羊和山羊养殖场存在胃肠道线虫,其次是线虫。(84.44%的绵羊和48.89%的山羊),Monieziaspp.(绵羊占73.33%,山羊占35.56%),毛虫(48.89%绵羊和42.22%山羊),肺虫(28.89%的绵羊和42.22%的山羊),乳头类圆线虫(40%绵羊和26.67%山羊),树枝状双壳菌(13.33%绵羊和26.67%山羊),Calicophorondaubneyi(6.67%的绵羊和31.11%的山羊),肝片吸虫(6.67%绵羊和4.44%山羊),和卵巢Skrjabinema(4.44%的绵羊和山羊)。调查问卷显示,82%和85%的农民采用了牧场轮作,在前一年中,有93.3%和86.6%的人对绵羊和山羊使用了驱虫药,分别。在处理之前,只有24.4%的养羊户和11.3%的养羊户进行了寄生虫学测试。最常用的驱虫药是大环内酯和苯并咪唑,只有21.6%和15.6%,对于绵羊和山羊来说,分别,进行药物轮换。这些结果表明,蠕虫代表了小反刍动物的健康问题,并突显了农民缺乏对寄生虫控制策略的了解。在这些条件下,驱虫抵抗现象可能随着时间的推移而发展。因此,有必要实施所有可能的控制蠕虫的策略,并防止驱虫抗药性现象在意大利南部农场的传播。
    Anthelmintic resistance in small ruminants is a serious worldwide problem. To reduce their spread, it is essential to know the prevalence of helminths on farms and the control practices adopted. As these studies in the Calabria region of southern Italy are fragmentary and outdated, a study on the prevalence of helminths in small ruminant holdings in this area has been conducted. The measures implemented to control helminths were also evaluated through questionnaires administered to farmers. In particular, on 90 farms (45 sheep and 45 goats), 1800 faecal samples from 900 sheep and 900 goats were collected in the spring. Using the FLOTAC dual technique, parasitological examinations demonstrated the presence of gastrointestinal nematodes in 100% of sheep and goat farms, followed by Nematodirus spp. (84.44% sheep and 48.89% goats), Moniezia spp. (73.33% sheep and 35.56% goats), Trichuris ovis (48.89% sheep and 42.22% goats), lungworms (28.89% sheep and 42.22% goats), Strongyloides papillosus (40% sheep and 26.67% goats), Dicrocoelium dendriticum (13.33% sheep and 26.67% goats), Calicophoron daubneyi (6.67% sheep and 31.11% goats), Fasciola hepatica (6.67% sheep and 4.44% goats), and Skrjabinema ovis (4.44% sheep and goats). The questionnaires showed that 82% and 85% of the farmers had applied pasture rotation, and that 93.3% and 86.6% had used anthelmintics in the previous year for sheep and goats, respectively. Only 24.4% of sheep farmers and 11.3% of goat farmers had carried out parasitological tests prior to treatments. The most used classes of anthelmintics were macrocyclic lactones and benzimidazoles, and only in 21.6% and 15.6%, for sheep and goats, respectively, was drug rotation carried out. These results denote that helminths represent a health problem for small ruminants and highlight a lack of knowledge of parasite control strategies among farmers. In these conditions, anthelmintic resistance phenomena could develop over time. Therefore, it is necessary to implement all possible strategies for the control of helminths, and to prevent the spread of anthelmintic resistance phenomena on farms in southern Italy.
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  • 文章类型: Journal Article
    (1)背景:本研究调查了在发展中国家的背景下,体重指数(BMI)类别与合并症之间的关系,利用蒙古全国健康检查的数据。(2)方法:该研究包括来自基于人群的一般健康筛查的181,080名个体(平均年龄47.0±15.3,男性占42.0%)。我们根据ICD-10代码从参与者的医疗记录中计算疾病的数量,不包括分类为Z00-Z99和指示急性疾病的代码,以及被归类为体重不足的个人。(3)结果:在研究参与者中,两种或两种以上合并症的患病率为4.2%.体重分布包括正常体重40.4%;37.1%超重;和16.9%,4.4%,在第一类中为1.2%,II,和III类肥胖,分别。合并症随着BMI的增加而增加:正常体重(0.222);超重(0.255);和I类(0.290),II类(0.302),和III类肥胖(0.303),提示多种疾病的剂量依赖性可能性。调整后的线性回归(β系数,95%CIs)显示超重(0.017,0.013-0.021)和肥胖(0.034,0.030-0.039)的合并症风险增加。与年龄的交互作用分析显示出显著的效应(p<0.001)。虽然合并症在所有年龄组中随着BMI类别的增加而增加,这种关联在年轻人中明显更强.(4)结论:与正常体重相比,肥胖与多种合并症的患病率增加两倍有关。我们的发现还强调了年龄在多种疾病发展中的关键作用,BMI仍然是各个年龄段的重要因素,包括年轻人和老年人。
    (1) Background: This study investigated the association between body mass index (BMI) categories and comorbidities in the context of a developing country, utilizing data from a nationwide health screening in Mongolia. (2) Methods: The study included 181,080 individuals (mean age 47.0 ± 15.3, 42.0% male) from the population-based general health screening. We counted the number of diseases from participants\' medical records based on ICD-10 codes, excluding those categorized under Z00-Z99 and codes indicating acute disorders, as well as individuals classified as underweight. (3) Results: Among study participants, the prevalence of two or more comorbidities was 4.2%. The weight distribution comprised 40.4% normal weight; 37.1% overweight; and 16.9%, 4.4%, and 1.2% in the Class I, II, and III obesity categories, respectively. Comorbidities increased with BMI: normal weight (0.222); overweight (0.255); and Class I (0.290), Class II (0.302), and Class III obesity (0.303), suggesting a dose-dependent likelihood of having multiple diseases. Adjusted linear regression (beta coefficients, 95% CIs) showed increased comorbidity risks in overweight (0.017, 0.013-0.021) and obesity (0.034, 0.030-0.039). Interaction analysis with age revealed a significant effect (p < 0.001). While comorbidities tend to increase with higher BMI categories in all age-tertile groups, this association was notably stronger among younger individuals. (4) Conclusions: Obesity is associated with a twofold increase in the prevalence of multiple comorbidities compared to normal weight. Our findings also highlight the critical role of age in the development of multiple diseases, with BMI remaining a significant factor across various age groups, encompassing both younger and older adults.
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  • 文章类型: Journal Article
    公共卫生信息学领域近年来经历了重大的演变,技术及其应用的进步对于应对新出现的公共卫生挑战至关重要。跨学科方法和培训可以帮助应对这些挑战。2023年,首届公共卫生信息与技术(PHIAT)会议在加利福尼亚大学成立,为期3天的混合会议。圣地亚哥,和在线。会议的目标是为学者和公共卫生组织建立一个论坛,以讨论和应对公共卫生信息学和技术领域的新机遇和挑战。本文概述了对利益的追求,演讲者和主题,与会者的评价,和吸取的教训将在今后的会议上得到落实。
    The field of public health informatics has undergone significant evolution in recent years, and advancements in technology and its applications are imperative to address emerging public health challenges. Interdisciplinary approaches and training can assist with these challenges. In 2023, the inaugural Public Health Informatics and Technology (PHIAT) Conference was established as a hybrid 3-day conference at the University of California, San Diego, and online. The conference\'s goal was to establish a forum for academics and public health organizations to discuss and tackle new opportunities and challenges in public health informatics and technology. This paper provides an overview of the quest for interest, speakers and topics, evaluations from the attendees, and lessons learned to be implemented in future conferences.
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  • 文章类型: Journal Article
    曼氏血吸虫引起一种水传播寄生虫病,称为血吸虫病。它通常影响缺乏卫生结构的个人。在巴西,帕拉州将贝伦列为2023年卫生条件最差的地方之一,血吸虫病的传播已经记录在案。这项研究报告了IlhadasOnças居民中血吸虫病的发生,贝伦旁边的一个岛。粪便样本来自2岁以上的参与者,所有来自富罗多里奥格兰德的居民,岛上的一条河流。采用Kato-Katz技术对粪便样本中的寄生虫进行调查。每位参与者都回答了社会人口统计学和临床问卷。对住宅进行了地理参考,以进行地图设计。263名参与者中有3名是S.mansoni阳性,所有的男人,年龄从19岁到41岁,低寄生负载。进行了疟疾调查,但没有发现Biomphalaria蜗牛.岛上存在血吸虫病的危险因素,缺乏卫生设施使其成为潜在的风险领域。高度鼓励将疟疾调查作为预防措施,以及对河边人群的健康监测,生成有助于卫生当局管理和规划预防性控制措施的数据。
    Schistosoma mansoni worms cause a waterborne parasitic disease called schistosomiasis. It commonly affects individuals in lack of sanitation structure. In Brazil, Pará state has Belém as one of the worst sanitation-ranking places in 2023, where schistosomiasis transmission was already documented. This study reports the occurrence of schistosomiasis in residents of Ilha das Onças, an island next to Belém. Stool samples were obtained from participants over 2 years old, all residents from Furo do Rio Grande, one of the rivers on the island. The Kato-Katz technique was performed for parasite investigation in the stool samples. Each participant responded to a sociodemographic and clinical questionnaire. The residences were georeferenced for map designing. Three out of 263 participants were S. mansoni positive, all men, ages ranging from 19 to 41 years old, with low parasitic load. Malacological surveys were carried out, but no Biomphalaria snails were found. Risk factors for schistosomiasis establishment are present on the island, and the lack of sanitation makes it a potential risk area. Malacological surveys are highly encouraged as preventive measures, as well as health surveillance for riverside populations, generating data that will help health authorities in the management and planning of preventive control actions.
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  • 文章类型: Journal Article
    糖尿病,一种以高血糖为特征的代谢性疾病,已被视为迅速升级的全球健康危机。到2021年,中国目前有1.409亿糖尿病人口,是全球最大的糖尿病人口。DM在过去的几十年里见证了巨大的增长,导致这种疾病造成的总体负担惊人地上升。监测近实时DM患病率和一线抗糖尿病药物的消耗,在中国237个城市实施了基于二甲双胍浓度反算的废水流行病学(WBE)方法.采用LC-MS/MS对废水中二甲双胍进行定量分析,方法验证结果满意。废水中二甲双胍的平均浓度为14.07±13.16μg/L,人均消费量为5.16±2.08毫克/天/每小时,范围从0.90到10.36±4.63毫克/天/每小时。计算的二甲双胍患病率为0.52%±0.28%,最终估计DM患病率为11.33%±4.99%,这与国际糖尿病联合会9.98%的调查结果几乎一致。结果表明,二甲双胍可能是糖尿病监测中合适的WBE生物标志物之一,WBE策略可能有助于在合理校正相关参数后估计中国大多数城市的DM患病率。
    Diabetes mellitus, a metabolic disease characterized by hyperglycemia, has been witnessed as a rapidly escalating worldwide health crisis. China currently had 140.9 million diabetic population in 2021, which was the largest globally. DM has witnessed a significant surge in the past few decades, leading to an alarming rise in the overall burden caused by this disease. To monitor the near real-time DM prevalence and the consumption of first-line anti-diabetic drugs, a wastewater-based epidemiology (WBE) approach based on the back-calculation of metformin concentration was implemented in 237 cities in China. The quantitative analysis of metformin in wastewater was conducted by LC-MS/MS with satisfactory results of method validation. The average concentration of metformin in wastewater was 14.07 ± 13.16 μg/L, and the per capita consumption was 5.16 ± 2.08 mg/day/inh, ranging from 0.90 to 10.36 ± 4.63 mg/day/inh. The calculated metformin prevalence was found to be 0.52 % ± 0.28 %, and the final estimated DM prevalence was 11.33 % ± 4.99 %, which was nearly consistent with the result of the International Diabetes Federation survey of 9.98 %. The results suggested that metformin might be one of the suitable WBE biomarkers in DM monitoring and WBE strategy could potentially enable the estimation of DM prevalence in most of Chinese cities after reasonable correction of associated parameters.
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  • 文章类型: Journal Article
    背景:缺乏关于甲状腺疾病的流行病学数据,特别是对于职业暴露人群。
    目的:比较法国农场管理者(FMs)完整人群中农业活动之间甲状腺功能减退和甲状腺功能亢进的风险。
    方法:来自回顾性管理数据库的数字健康数据,包括保险索赔和电子健康/医疗记录,被雇用。该队列数据涵盖了从2002年到2016年至少从事过一次工作的整个法国农场管理者(FM)。以初始药物报销时间为时间尺度的生存分析用于检查相关性(风险比,HR)介于26种特定的耕作活动与治疗的甲状腺功能减退和甲状腺功能亢进之间。为每个农业活动开发了一个不同的模型,将2002年至2016年间从未从事过特定农业活动的FM与从事过特定农业活动的FM进行比较。所有分析均针对潜在的混杂因素进行了调整(例如,年龄),并进行了敏感性分析。
    结果:在1088561名FMs中(平均年龄46.6[SD14.1];31%的女性),有31834例甲状腺功能减退(75%女性)和620例甲状腺功能亢进(67%女性),分别。对于甲状腺功能亢进(HR范围为1.75至2.42)和甲状腺功能减退症(HR范围为1.41至1.44),牛的活动风险最高。对于甲状腺功能减退,在几种动物养殖活动中也观察到更高的风险(猪,家禽,和兔子),以及水果树木栽培(HR=1.22[1.14-1.31])。涉及马的活动风险最低。在8种活动中观察到甲状腺功能减退症风险的性别差异,在葡萄栽培中,男性(HR=1.09[1.01-1.20])的风险高于女性(HR=0.97[0.93-1.00])。男性奶农患甲亢的风险是女性的两倍。
    结论:我们的研究结果全面概述了FM社区的甲状腺疾病风险。甲状腺疾病可能不是由单一原因引起的,而是可能由各种病因和触发因素(农业暴露)的综合作用引起的。进一步调查不同的农业活动,特别是涉及牛的活动,对于查明可能加强农业甲状腺疾病监测的潜在风险因素至关重要。
    BACKGROUND: Epidemiological data regarding thyroid diseases are lacking, in particular for occupationally exposed populations.
    OBJECTIVE: To compare the risk of hypothyroidism and hyperthyroidism between farming activities within the complete population of French farm managers (FMs).
    METHODS: Digital health data from retrospective administrative databases, including insurance claims and electronic health/medical records, was employed. This cohort data spanned the entirety of French farm managers (FMs) who had undertaken work at least once from 2002 to 2016. Survival analysis with the time to initial medication reimbursement as timescale was used to examine the association (hazard ratio, HR) between 26 specific farming activities and both treated hypothyroidism and hyperthyroidism. A distinct model was developed for each farming activity, comparing FMs who had never engaged in the specific farming activity between 2002 and 2016 with those who had. All analyses were adjusted for potential confounders (e.g., age), and sensitivity analyses were conducted.
    RESULTS: Among 1088561 FMs (mean age 46.6 [SD 14.1]; 31% females), there were 31834 hypothyroidism cases (75% females) and 620 hyperthyroidism cases (67% females), respectively. The highest risks were observed for cattle activities for both hyperthyroidism (HR ranging from 1.75 to 2.42) and hypothyroidism (HR ranging from 1.41 to 1.44). For hypothyroidism, higher risks were also observed for several animal farming activities (pig, poultry, and rabbit), as well as fruit arboriculture (HR = 1.22 [1.14-1.31]). The lowest risks were observed for activities involving horses. Sex differences in the risk of hypothyroidism were observed for eight activities, with the risk being higher for males (HR = 1.09 [1.01-1.20]) than females in viticulture (HR = 0.97 [0.93-1.00]). The risk of hyperthyroidism was two times higher for male dairy farmers than females.
    CONCLUSIONS: Our findings offer a comprehensive overview of thyroid disease risks within the FM community. Thyroid ailments might not stem from a single cause but likely arise from the combined effects of various causal agents and triggering factors (agricultural exposome). Further investigation into distinct farming activities-especially those involving cattle-is essential to pinpoint potential risk factors that could enhance thyroid disease monitoring in agriculture.
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