Abstract：
UNASSIGNED: Exposure to hazardous substances in the workplace can result in injuries and fatalities. This study aimed to investigate the characteristics and trend of occupational exposures reported to the Dutch Poisons Information Centre and to investigate whether the COVID-19 pandemic had an impact on the trend.
UNASSIGNED: A retrospective analysis of all acute occupational exposures reported to the Dutch Poisons Information Centre between 1 January 2016 and 31 December 2022 was performed. Data on patient and exposure characteristics, symptoms and treatment recommendations were analyzed.
UNASSIGNED: Between 2016 and 2022, the Dutch Poisons Information Centre received 5,508 calls regarding acute occupational exposures. The annual number of calls on acute occupational exposures almost doubled over the years studied (from 475 in 2016 to 936 in 2022). During and after the COVID-19 pandemic (March 2020-December 2022), the number of calls stabilized, but the upward trend was not significantly affected. There were an estimated 0.20 calls per 1,000 human exposure calls per month (95 per cent confidence interval: -0.14; 0.53). Victims were often exposed through multiple routes, with inhalation being the most common route (44 per cent), followed by ocular (32 per cent) and dermal contact (30 per cent). Acids (1,138 exposures) and alkalis (912 exposures) were often involved. The Dutch Poisons Information Centre had information on 6,334 patients, although the total number of exposed patients was not known as some victims did not seek medical assistance, or were treated by healthcare professionals who did not consult our Centre. At the time of contact, 13 per cent (n = 795) of the patients reported no symptoms, 76 per cent (n = 4,805) reported mild to moderate symptoms and 3 per cent (n = 183) reported potentially severe symptoms. Information on symptoms was missing for 9 per cent (n = 551) of the patients. Hospital observation and treatment were recommended for 5 per cent (n = 325) of the patients.
UNASSIGNED: This study highlights the necessity for poisoning prevention strategies to reduce the number of work-related incidents involving hazardous substances.
UNASSIGNED: The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous substances and to identify risk factors.
UNASSIGNED: A retrospective analysis of all acute occupational exposures reported to the Dutch Poisons Information Centre between 1 January 2016 and 31 December 2022 was performed. Data on patient and exposure characteristics, symptoms and treatment recommendations were analyzed.
UNASSIGNED: Between 2016 and 2022, the Dutch Poisons Information Centre received 5,508 calls regarding acute occupational exposures. The annual number of calls on acute occupational exposures almost doubled over the years studied (from 475 in 2016 to 936 in 2022). During and after the COVID-19 pandemic (March 2020-December 2022), the number of calls stabilized, but the upward trend was not significantly affected. There were an estimated 0.20 calls per 1,000 human exposure calls per month (95 per cent confidence interval: -0.14; 0.53). Victims were often exposed through multiple routes, with inhalation being the most common route (44 per cent), followed by ocular (32 per cent) and dermal contact (30 per cent). Acids (1,138 exposures) and alkalis (912 exposures) were often involved. The Dutch Poisons Information Centre had information on 6,334 patients, although the total number of exposed patients was not known as some victims did not seek medical assistance, or were treated by healthcare professionals who did not consult our Centre. At the time of contact, 13 per cent (n = 795) of the patients reported no symptoms, 76 per cent (n = 4,805) reported mild to moderate symptoms and 3 per cent (n = 183) reported potentially severe symptoms. Information on symptoms was missing for 9 per cent (n = 551) of the patients. Hospital observation and treatment were recommended for 5 per cent (n = 325) of the patients.
UNASSIGNED: This study highlights the necessity for poisoning prevention strategies to reduce the number of work-related incidents involving hazardous substances.
UNASSIGNED: The continuing increase in the number of workplace incidents involving hazardous substances is of concern. A comprehensive and multidisciplinary approach should be taken to gain a full understanding of occupational exposure to hazardous substances and to identify risk factors.
摘要：
在工作场所接触有害物质会导致人员受伤和死亡。这项研究旨在调查向荷兰毒物信息中心报告的职业暴露的特征和趋势，并调查COVID-19大流行是否对趋势产生影响。
对2016年1月1日至2022年12月31日期间向荷兰毒物信息中心报告的所有急性职业暴露进行了回顾性分析。有关患者和暴露特征的数据，分析症状及治疗建议。
■在2016年至2022年之间，荷兰毒物信息中心收到了5,508个有关急性职业暴露的电话。在研究的这些年中，关于急性职业暴露的年度电话数量几乎翻了一番（从2016年的475个增加到2022年的936个）。在COVID-19大流行期间和之后（2020年3月至2022年12月），电话数量稳定了,但上升趋势并未受到明显影响。估计每月每1000个人类接触电话中有0.20个电话(95%置信区间:-0.14;0.53)。受害者经常通过多种途径暴露，吸入是最常见的途径(44%)，其次是眼部(32%)和皮肤接触(30%)。经常涉及酸（1,138次暴露）和碱（912次暴露）。荷兰毒物信息中心掌握了6,334名病人的资料,尽管暴露的患者总数未知，因为一些受害者没有寻求医疗援助，或由未咨询我们中心的医疗保健专业人员治疗。在接触的时候,13%(n=795)的患者报告没有症状，76%(n=4,805)报告轻度至中度症状，3%(n=183)报告潜在严重症状。9％（n=551）的患者缺少症状信息。建议5%(n=325)的患者接受医院观察和治疗。
■这项研究强调了中毒预防策略的必要性，以减少涉及有害物质的与工作有关的事件的数量。
■涉及有害物质的工作场所事故数量的持续增加令人担忧。应采取全面和多学科的方法，以充分了解危险物质的职业暴露情况，并确定危险因素。
对2016年1月1日至2022年12月31日期间向荷兰毒物信息中心报告的所有急性职业暴露进行了回顾性分析。有关患者和暴露特征的数据，分析症状及治疗建议。
■在2016年至2022年之间，荷兰毒物信息中心收到了5,508个有关急性职业暴露的电话。在研究的这些年中，关于急性职业暴露的年度电话数量几乎翻了一番（从2016年的475个增加到2022年的936个）。在COVID-19大流行期间和之后（2020年3月至2022年12月），电话数量稳定了,但上升趋势并未受到明显影响。估计每月每1000个人类接触电话中有0.20个电话(95%置信区间:-0.14;0.53)。受害者经常通过多种途径暴露，吸入是最常见的途径(44%)，其次是眼部(32%)和皮肤接触(30%)。经常涉及酸（1,138次暴露）和碱（912次暴露）。荷兰毒物信息中心掌握了6,334名病人的资料,尽管暴露的患者总数未知，因为一些受害者没有寻求医疗援助，或由未咨询我们中心的医疗保健专业人员治疗。在接触的时候,13%(n=795)的患者报告没有症状，76%(n=4,805)报告轻度至中度症状，3%(n=183)报告潜在严重症状。9％（n=551）的患者缺少症状信息。建议5%(n=325)的患者接受医院观察和治疗。
■这项研究强调了中毒预防策略的必要性，以减少涉及有害物质的与工作有关的事件的数量。
■涉及有害物质的工作场所事故数量的持续增加令人担忧。应采取全面和多学科的方法，以充分了解危险物质的职业暴露情况，并确定危险因素。
