■各种胰岛素抵抗替代品与虚弱之间的相关性仍在科学界进行研究。
■使用来自NHANES(1999-2018)的数据。我们利用加权二元逻辑回归,趋势测试,RCS分析,和亚组分析,全面评估METS-IR之间的联系,HOMA-IR,和TyG,和脆弱的风险。
■结果显示高水平的METS-IR,HOMA-IR,和TyG在所有型号中都有脆弱的风险。值得注意的是,在模型4中,METS-IR的最高五分位数显示出最强的联系(OR:2.960,95%CI:2.219-3.949),HOMA-IR(OR:2.522,95%CI:1.927-3.301)紧随其后。趋势测试表明,METS-IR之间存在积极趋势,HOMA-IR,和TyG具有虚弱的风险(P为趋势<0.05)。RCS分析显示METS-IR与衰弱风险呈线性关系(非线性P>0.05)。相比之下,HOMA-IR和TyG呈现U型非线性关系(非线性P<0.05)。
■研究确定了METS-IR与虚弱风险之间的线性关联,而HOMA-IR和TyG显示为U形,与脆弱风险的非线性关系模式。在检查的不同级别中,METS-IR与虚弱之间的联系在前五分之一中最为明显。
UNASSIGNED: The correlation between various insulin resistance surrogates and frailty remains under investigation in the scientific community.
UNASSIGNED: Data from NHANES (1999-2018) were used. We utilized weighted binary logistic regression, trend tests, RCS analysis, and subgroup analysis to comprehensively assess the link between METS-IR, HOMA-IR, and TyG, and frailty risk.
UNASSIGNED: The results revealed a significant positive association between high levels of METS-IR, HOMA-IR, and TyG with the risk of frailty in all models. Notably, in model 4, the highest quintile of METS-IR showed the strongest link (OR: 2.960, 95% CI: 2.219-3.949), with HOMA-IR (OR: 2.522, 95% CI: 1.927-3.301) following closely behind. Trend tests revealed a positive trend between METS-IR, HOMA-IR, and TyG with the risk of frailty (P for trend < 0.05). RCS analysis showed a linear relationship between METS-IR and the risk of frailty (P for nonlinearity > 0.05). In contrast, HOMA-IR and TyG exhibited a U-shaped nonlinear relationship (P for nonlinearity < 0.05).
UNASSIGNED: The research identified a linear association between METS-IR and frailty risk, whereas HOMA-IR and TyG displayed a U-shaped, nonlinear relationship pattern with the risk of frailty. Among the varying levels examined, the linkage between METS-IR and frailty was most pronounced in the top quintile.