{Reference Type}: Journal Article
{Title}: Postmenopausal women treated for breast cancer with insulin resistance: clinical, analytical, cross-sectional.
{Author}: Orsatti CL;Orsatti FL;De Souza JPEA;de Araujo Brito Buttros D;Nahas EAP;
{Journal}: Women Health
{Volume}: 64
{Issue}: 7
{Year}: 2024 Aug 31
{Factor}: 1.708
{DOI}: 10.1080/03630242.2024.2383289
{Abstract}: This study aims to investigate the potential association between serum levels of cytokines, HSP60, HSP70 and IR (HOMA-IR) in postmenopausal women. We conducted a cross-sectional study involving 381 postmenopausal women, including 94 with a breast cancer diagnosis and 278 without. We analyzed anthropometric and laboratory measurements. Immunoassays were used to measure cytokines (TNF-α, IL-10, and IL-6) as well as heat shock proteins (HSP) 60 and 70 in the serum using the ELISA technique. Women diagnosed with breast cancer showed higher levels of HOMA-IR, IL-6, TNF, and HSP60, and lower levels of IL-10 and HSP70 compared to women without cancer. An association was found between HSP70 and HOMA-IR only in women with breast cancer (β = 0.22, p = .030; without cancer: β = 0.04, p = .404), regardless of age, waist circumference, smoking, and physical activity. No associations were observed between cytokines, HSP60, and HOMA-IR in both groups of women. HSP70 is positively associated with IR in women diagnosed with breast cancer.