■桥本甲状腺炎(HT)的标志包括通过导致胰岛素抵抗(IR)而破坏甲状腺细胞,甲状腺功能减退,和代谢异常。Kisspeptin,spexin,和甘丙肽控制食欲和体重(BW)以调节代谢。这里,我们试图确定加兰宁,kisspeptin,和spexin与甲状腺功能正常的女性患者HT的病理生理学有关。
■45名患有HT的妇女和45名相同年龄的健康对照妇女参加了本研究。采用酶联免疫吸附试验(ELISA)法测定血清甘丙肽水平,spexin,和kisspeptin.
■与对照组相比,HT患者的kisspeptin水平明显升高(p<0.01),甘丙肽(p<0.01),抗甲状腺过氧化物酶(抗TPO)(p<0.001),抗甲状腺球蛋白(抗Tg)(p<0.001),体重指数(BMI)(p<0.05)。两组在spexin方面具有可比性,游离三碘甲状腺原氨酸-3(fT3),fT4,促甲状腺激素(TSH)水平,和胰岛素抵抗的稳态模型评估(HOMA-IR)。甘丙肽与kisspeptin呈正相关(p<0.01;r=0.786)。
■甲状腺功能正常的HT女性被发现具有较高水平的kisspeptin和galanin。这些结果表明,kisspeptin和galanin可能与甲状腺功能减退的发病机制有关,结果,我们认为这些标志物可能对HT患者的早期发现和治疗有益.
UNASSIGNED: The hallmarks of Hashimoto\'s thyroiditis (HT) include the destruction of thyroid cells by leading to insulin resistance (IR), hypothyroidism, and metabolic abnormalities. Kisspeptin, spexin, and
galanin control appetite and body weight (BW) to regulate metabolisms. Here, we sought to determine if
galanin, kisspeptin, and spexin are linked to the pathophysiology of HT in euthyroid female individuals.
UNASSIGNED: Forty-five women with HT and 45 healthy control women of the same age participated in the current study. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the serum levels of
galanin, spexin, and kisspeptin.
UNASSIGNED: In comparison to the controls, HT patients had significantly higher levels of kisspeptin (p < 0.01), galanin (p < 0.01), anti-thyroid peroxidase (anti-TPO) (p < 0.001), anti-thyroglobulin (anti-Tg) (p < 0.001), and body mass index (BMI) (p < 0.05). The two groups were comparable in terms of spexin, free triiodothyronine-3 (fT3), fT4, thyroid-stimulating hormone (TSH) levels, and homeostatic model assessment for insulin resistance (HOMA-IR).
Galanin and kisspeptin were seen to have a positive correlation (p < 0.01; r = 0.786).
UNASSIGNED: Euthyroid women with HT were found to have higher levels of kisspeptin and galanin. These results imply that kisspeptin and
galanin may be linked to the pathogenesis of hypothyroidism, and as a result, we believe that these markers may be beneficial in the early detection and treatment of HT patients.