PDF(Pubmed)
Abstract：
Bisphenols are dangerous endocrine disruptors that pollute the environment. Due to their chemical properties, they are globally used to produce plastics. Structural similarities to oestrogen allow bisphenols to bind to oestrogen receptors and affect internal body systems. Most commonly used in the plastic industry is bisphenol A (BPA), which also has negative effects on the nervous, immune, endocrine, and cardiovascular systems. A popular analogue of BPA-bisphenol S (BPS) also seems to have harmful effects similar to BPA on living organisms. Therefore, with the use of double immunofluorescence labelling, this study aimed to compare the effect of BPA and BPS on the enteric nervous system (ENS) in mouse jejunum. The study showed that both studied toxins impact the number of nerve cells immunoreactive to substance P (SP), galanin (GAL), vasoactive intestinal polypeptide (VIP), the neuronal isoform of nitric oxide synthase (nNOS), and vesicular acetylcholine transporter (VAChT). The observed changes were similar in the case of both tested bisphenols. However, the influence of BPA showed stronger changes in neurochemical coding. The results also showed that long-term exposure to BPS significantly affects the ENS.
摘要：
双酚是污染环境的危险的内分泌干扰物。由于它们的化学性质，它们在全球范围内用于生产塑料。与雌激素的结构相似性允许双酚与雌激素受体结合并影响体内系统。在塑料工业中最常用的是双酚A（BPA），这对神经也有负面影响，免疫，内分泌，和心血管系统。BPA-双酚S（BPS）的一种流行类似物似乎也对生物体具有类似于BPA的有害影响。因此,使用双重免疫荧光标记，本研究旨在比较BPA和BPS对小鼠空肠肠神经系统（ENS）的影响。研究表明，两种研究的毒素都会影响对P物质（SP）具有免疫反应性的神经细胞的数量，甘丙肽(GAL),血管活性肠多肽（VIP），一氧化氮合酶（nNOS）的神经元同工型，和囊泡乙酰胆碱转运蛋白（VAChT）。在两种测试的双酚的情况下观察到的变化是相似的。然而,BPA的影响表现出更强的神经化学编码变化。结果还表明，长期暴露于BPS会显着影响ENS。
