■非伤寒沙门氏菌(NTS)菌血症在撒哈拉以南非洲很常见。我们检测了抗生素对氟喹诺酮类药物的耐药性,第三代头孢菌素,来自撒哈拉以南非洲的NTS人类分离株的多药耐药性(MDR)。
■使用OvidMedline中的搜索进行了系统评价,Embase,和2000年至2021年间出版物的非洲索引医学。使用来自66项研究的数据进行了随机效应模型荟萃分析,这些研究包括29,039NTS血液和1,065个粪便分离株。
■血液中MDR的合并患病率比例分别为0.685(95%CI0.574-0.778)和0.214(0.020-0.785)。粪便分离物。氟喹诺酮类药物耐药性的相应估计值为0.014(0.008-0.025)与0.021(0.012-0.036)和第三代头孢菌素耐药性0.019(0.012-0.031)与0.035(0.006-0.185)。儿童和成人也有类似的结果。在2000-2010年和2011-2021年间,血液分离物中对这些抗生素的耐药率增加。用于确定抗菌素耐药性和流行病学特征的指南(例如,研究持续时间)与耐药患病率相关。
■在撒哈拉以南非洲的NTS中,MDR的流行以及对氟喹诺酮和第三代头孢菌素的耐药性令人震惊。
在撒哈拉以南非洲地区,对NTS抗菌药物耐药性进行标准化监测是必要的,以指导医疗保健政策制定和抗生素管理计划。
非伤寒沙门氏菌(NTS)通常会引起腹泻病,但有些病人可能会出现血流感染.在撒哈拉以南非洲,由NTS引起的血流感染的发生率和病死率很高。然而,有关该地区这些细菌的抗生素耐药性的信息很少。我们进行了系统评价和荟萃分析,以检查撒哈拉以南非洲患者NTS分离株的多药耐药性(MDR)和对用于治疗NTS血流感染的抗生素的耐药性:氟喹诺酮类药物和第三代头孢菌素。我们使用了66项研究的数据。在NTS血液分离物中,氟喹诺酮类药物耐药的合并患病率为1.4%,对第三代头孢菌素的耐药性为1.9%,MDR为68.5%。这些估计是2.1%,3.5%,粪便分离物中占21.4%。在过去的20年中,血液分离物中对氟喹诺酮类药物和第三代头孢菌素类药物的耐药性患病率有所增加。用于确定抗菌素耐药性的指南和研究的流行病学特征与耐药性流行有关。NTS中MDR的高患病率引起了人们的关注,对氟喹诺酮类和第三代头孢菌素类耐药的出现令人担忧。加强对NTS抗菌药物耐药性的监测对于指导撒哈拉以南非洲患者的护理和决策至关重要。
UNASSIGNED: Non-typhoidal Salmonella (NTS) bacteremia is common in sub-Saharan Africa. We examined the prevalence of antibiotic resistance to
fluoroquinolones, third-generation cephalosporins, and multi-drug resistance (MDR) in NTS human isolates from sub-Saharan Africa.
UNASSIGNED: A systematic review was conducted using a search in Ovid Medline, Embase, and African Index Medicus of publications between 2000 and 2021. A random-effects model meta-analysis was performed using data from 66 studies that included 29,039 NTS blood and 1,065 stool isolates.
UNASSIGNED: The pooled prevalence proportions of MDR were 0.685 (95% CI 0.574-0.778) and 0.214 (0.020-0.785) in blood vs. stool isolates. The corresponding estimates of
fluoroquinolones resistance were 0.014 (0.008-0.025) vs. 0.021 (0.012-0.036) and third-generation cephalosporins resistance 0.019 (0.012-0.031) vs. 0.035 (0.006-0.185). Similar results were found for children and adults. Resistance prevalence to these antibiotics in blood isolates increased between 2000-2010 and 2011-2021. The guidelines employed to determine antimicrobial resistance and epidemiological characteristics (e.g. sample size, study duration) correlated with the resistance prevalence.
UNASSIGNED: The prevalence of MDR and resistance to
fluoroquinolones and third-generation cephalosporins in NTS in sub-Saharan Africa is alarming.
UNASSIGNED: Standardized surveillance of antimicrobial drug resistance in NTS in sub-Saharan Africa is warranted to guide healthcare policymaking and antibiotic stewardship programs.
Non-typhoidal Salmonella (NTS) usually causes diarrheal disease, but some patients might develop bloodstream infection. The occurrence and case fatality of bloodstream infections caused by NTS are high in sub-Saharan Africa. However, the information on antibiotic resistance of these bacteria in this region is scarce. We performed a systematic review and meta-analysis to examine the prevalence of multi-drug resistance (MDR) and resistance to antibiotics used to treat NTS bloodstream infection: fluoroquinolones and third-generation cephalosporins in NTS isolates from patients from sub-Saharan Africa.We used data from 66 studies. In NTS blood isolates, the combined prevalence was 1.4% for
fluoroquinolones resistance, 1.9% for resistance to third-generation cephalosporins, and 68.5% for MDR. These estimates were 2.1%, 3.5%, and 21.4% in stool isolates. The prevalence of resistance to
fluoroquinolones and third-generation cephalosporins in blood isolates has increased in the past 2 decades. The guidelines employed to determine antimicrobial resistance and the study epidemiological characteristics were related to the resistance prevalence.The high prevalence of MDR in NTS raises concerns, and the emergence of resistance to fluoroquinolones and third-generation cephalosporins is worrisome. Strengthening the monitoring of antimicrobial drug resistance in NTS is essential to guide patients’ care and policymaking in sub-Saharan Africa.