■这项研究的目的是使用参数有限元建模和实验设计(DOE)方法研究眼球和视神经(ON)形态和组织刚度对凝视引起的视神经头变形的影响。
■开发了一种自定义软件,用于使用10个形态学参数生成眼睛的有限元模型:硬脑膜半径,巩膜,脉络膜,视网膜,毛管和乳头周围边界组织厚度,前层组织深度,筛板(LC)深度,在半径上,和弯曲。使用中心复合面为中心的设计(1045模型)来预测每种形态因子及其相互作用对13度内收诱导的LC菌株的影响。随后,进行了进一步的DOE分析(1045个模型),以研究从初始DOE研究中确定的前5个形态参数与5个关键组织硬度之间的影响和潜在的相互作用.
■在10个形态参数的DOE分析中,5个最重要的因素是弯曲,硬脑膜半径,在半径上,巩膜厚度,LC深度结合生物力学参数的进一步DOE分析强调了硬脑膜和LC刚度的重要性。较大的硬脑膜半径和硬脑膜增加了LC应变,但其他主要因素具有相反的作用。值得注意的是,硬脑膜半径与硬脑膜刚度之间存在显著的相互作用,在半径上,和弯曲。
■这项研究强调了形态因素对眼球运动过程中LC变形的重大影响,关键的形态效应比组织僵硬更明显。
UNASSIGNED: The purpose of this study was to investigate the effect of globe and optic nerve (ON) morphologies and tissue stiffnesses on gaze-induced optic nerve head deformations using parametric finite element modeling and a design of experiment (DOE) approach.
UNASSIGNED: A custom software was developed to generate finite element models of the eye using 10 morphological parameters: dural radius, scleral, choroidal, retinal, pial and peripapillary border tissue thicknesses, prelaminar tissue depth, lamina cribrosa (LC) depth, ON radius, and ON tortuosity. A central composite face-centered design (1045 models) was used to predict the effects of each morphological factor and their interactions on LC strains induced by 13 degrees of adduction. Subsequently, a further DOE analysis (1045 models) was conducted to study the effects and potential interactions between the top five morphological parameters identified from the initial DOE study and five critical tissue stiffnesses.
UNASSIGNED: In the DOE analysis of 10 morphological parameters, the 5 most significant factors were ON tortuosity, dural radius, ON radius, scleral thickness, and LC depth. Further DOE analysis incorporating biomechanical parameters highlighted the importance of dural and LC stiffness. A larger dural radius and stiffer dura increased LC strains but the other main factors had the opposite effects. Notably, the significant interactions were found between dural radius with dural stiffness, ON radius, and ON tortuosity.
UNASSIGNED: This study highlights the significant impact of morphological factors on LC deformations during eye movements, with key morphological effects being more pronounced than tissue stiffnesses.